Abstract：
BACKGROUND: Anti-IgLON5 encephalitis was a rare neurological and heterogeneous disorder, which was mainly found in adults. Epileptic seizures related to anti-IgLON5 disease were rarely reported.
METHODS: Neural antibodies associated with autoimmune encephalitis in serum and cerebrospinal fluid (CSF) were tested using cell-based assays (CBA) with immunofluorescence double staining. The antibodies in serum were further confirmed by tissue-based assay (TBA) with rat brain and kidney tissue.
RESULTS: We reported a pediatric case presented with epileptic seizures, cognitive impairments, and sleep disorders. Autoantibody screening showed anti-IgLON5 antibody IgG (1:100+) and anti-NMDAR antibody IgG (1:10+) in the serum. She was diagnosed as anti-IgLON5 encephalitis. Her conditions improved rapidly by treated with intravenous immunoglobulin and high dose intravenous methylprednisolone.
CONCLUSIONS: We described the second pediatric case with anti-IgLON5 encephalitis, who was also the first presented with epileptic seizures as the initial presentation. Anti-IgLON5 encephalitis might have mild manifestations. For patients with new onset seizures associated with cognitive impairments and sleep disturbances, anti-IgLON5 antibody should be tested as early, even in children.
METHODS: Neural antibodies associated with autoimmune encephalitis in serum and cerebrospinal fluid (CSF) were tested using cell-based assays (CBA) with immunofluorescence double staining. The antibodies in serum were further confirmed by tissue-based assay (TBA) with rat brain and kidney tissue.
RESULTS: We reported a pediatric case presented with epileptic seizures, cognitive impairments, and sleep disorders. Autoantibody screening showed anti-IgLON5 antibody IgG (1:100+) and anti-NMDAR antibody IgG (1:10+) in the serum. She was diagnosed as anti-IgLON5 encephalitis. Her conditions improved rapidly by treated with intravenous immunoglobulin and high dose intravenous methylprednisolone.
CONCLUSIONS: We described the second pediatric case with anti-IgLON5 encephalitis, who was also the first presented with epileptic seizures as the initial presentation. Anti-IgLON5 encephalitis might have mild manifestations. For patients with new onset seizures associated with cognitive impairments and sleep disturbances, anti-IgLON5 antibody should be tested as early, even in children.
摘要：
背景：抗IgLON5脑炎是一种罕见的神经系统疾病，主要见于成人。很少报道与抗IgLON5疾病相关的癫痫发作。
方法：使用免疫荧光双重染色的基于细胞的测定法（CBA）检测血清和脑脊液（CSF）中与自身免疫性脑炎相关的神经抗体。血清中的抗体通过大鼠脑和肾组织的基于组织的测定(TBA)进一步证实。
结果：我们报道了一例出现癫痫发作的儿科病例，认知障碍，和睡眠障碍。自身抗体筛选显示血清中的抗IgLON5抗体IgG(1:100+)和抗NMDAR抗体IgG(1:10+)。她被诊断为抗IgLON5脑炎。通过静脉注射免疫球蛋白和大剂量静脉注射甲泼尼龙治疗，她的病情迅速改善。
结论：我们描述了第二例抗IgLON5脑炎的儿科病例，他也是第一个出现癫痫发作的人。抗IgLON5脑炎可能有轻度表现。对于与认知障碍和睡眠障碍相关的新发作癫痫患者，抗IgLON5抗体应尽早测试，即使在孩子们。
方法：使用免疫荧光双重染色的基于细胞的测定法（CBA）检测血清和脑脊液（CSF）中与自身免疫性脑炎相关的神经抗体。血清中的抗体通过大鼠脑和肾组织的基于组织的测定(TBA)进一步证实。
结果：我们报道了一例出现癫痫发作的儿科病例，认知障碍，和睡眠障碍。自身抗体筛选显示血清中的抗IgLON5抗体IgG(1:100+)和抗NMDAR抗体IgG(1:10+)。她被诊断为抗IgLON5脑炎。通过静脉注射免疫球蛋白和大剂量静脉注射甲泼尼龙治疗，她的病情迅速改善。
结论：我们描述了第二例抗IgLON5脑炎的儿科病例，他也是第一个出现癫痫发作的人。抗IgLON5脑炎可能有轻度表现。对于与认知障碍和睡眠障碍相关的新发作癫痫患者，抗IgLON5抗体应尽早测试，即使在孩子们。
