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Abstract：
BACKGROUND: The plasma uric acid to albumin ratio (UAR) is considered as a novel indicator for Inflammation. However, the association between UAR and coronary slow flow phenomenon (CSFP) remains unclear.
METHODS: A total of 1328 individuals with chronic coronary syndrome (CCS) receiving coronary angiography (CAG) and found no obvious obstructive stenosis (< 40%) were included in this study. 79 individuals developed CSFP and were divided into CSFP group. The 1:2 age-matched patients with normal coronary blood flow were allocated to the control group (n = 158). The clinical characteristics, laboratory parameters including uric acid, albumin ratio, UAR and the angiographic characteristics were compared between the two groups.
RESULTS: Patients with CSFP had a higher level of uric acid (392.3 ± 85.3 vs. 273.8 ± 71.5, P < 0.001), UAR (10.7 ± 2.2 vs. 7.2 ± 1.9, P < 0.001), but a lower level of plasma albumin (36.9 ± 4.2 vs. 38.5 ± 3.6, P = 0.003). Moreover, UAR increased as the numbers of vessels involved in CSFP increased. The logistic regression analysis demonstrated that UAR was independent predictors for CSFP. The Receiver operating characteristic (ROC) curve analysis showed that when UAR was more than 7.9, the AUC was 0.883 (95% CI: 0.840-0.927, p < 0.001), with the sensitivity and specificity were 78.2% and 88.2% respectively.
CONCLUSIONS: Combined uric acid with plasma albumin, UAR could serve as an independent predictor for CSFP.
METHODS: A total of 1328 individuals with chronic coronary syndrome (CCS) receiving coronary angiography (CAG) and found no obvious obstructive stenosis (< 40%) were included in this study. 79 individuals developed CSFP and were divided into CSFP group. The 1:2 age-matched patients with normal coronary blood flow were allocated to the control group (n = 158). The clinical characteristics, laboratory parameters including uric acid, albumin ratio, UAR and the angiographic characteristics were compared between the two groups.
RESULTS: Patients with CSFP had a higher level of uric acid (392.3 ± 85.3 vs. 273.8 ± 71.5, P < 0.001), UAR (10.7 ± 2.2 vs. 7.2 ± 1.9, P < 0.001), but a lower level of plasma albumin (36.9 ± 4.2 vs. 38.5 ± 3.6, P = 0.003). Moreover, UAR increased as the numbers of vessels involved in CSFP increased. The logistic regression analysis demonstrated that UAR was independent predictors for CSFP. The Receiver operating characteristic (ROC) curve analysis showed that when UAR was more than 7.9, the AUC was 0.883 (95% CI: 0.840-0.927, p < 0.001), with the sensitivity and specificity were 78.2% and 88.2% respectively.
CONCLUSIONS: Combined uric acid with plasma albumin, UAR could serve as an independent predictor for CSFP.
摘要：
背景：血浆尿酸与白蛋白之比（UAR）被认为是炎症的新型指标。然而,UAR与冠状动脉慢血流现象(CSFP)之间的关联尚不清楚.
方法：本研究共纳入1328例慢性冠脉综合征（CCS）患者行冠状动脉造影（CAG），未发现明显的阻塞性狭窄（<40％）。79例发生CSFP，分为CSFP组。将1：2年龄匹配的冠状动脉血流量正常的患者分配到对照组（n=158）。临床特点,实验室参数，包括尿酸，白蛋白比，比较两组的UAR和血管造影特征。
结果：CSFP患者的尿酸水平较高（392.3±85.3vs.273.8±71.5,P<0.001),UAR(10.7±2.2vs.7.2±1.9，P<0.001），但血浆白蛋白水平较低(36.9±4.2vs.38.5±3.6,P=0.003)。此外，UAR随着CSFP涉及的船只数量的增加而增加。Logistic回归分析显示UAR是CSFP的独立预测因子。受试者工作特征（ROC）曲线分析表明，当UAR大于7.9时，AUC为0.883（95％CI：0.840-0.927，p<0.001），敏感性和特异性分别为78.2%和88.2%。
结论：尿酸与血浆白蛋白联用，UAR可以作为CSFP的独立预测因子。
方法：本研究共纳入1328例慢性冠脉综合征（CCS）患者行冠状动脉造影（CAG），未发现明显的阻塞性狭窄（<40％）。79例发生CSFP，分为CSFP组。将1：2年龄匹配的冠状动脉血流量正常的患者分配到对照组（n=158）。临床特点,实验室参数，包括尿酸，白蛋白比，比较两组的UAR和血管造影特征。
结果：CSFP患者的尿酸水平较高（392.3±85.3vs.273.8±71.5,P<0.001),UAR(10.7±2.2vs.7.2±1.9，P<0.001），但血浆白蛋白水平较低(36.9±4.2vs.38.5±3.6,P=0.003)。此外，UAR随着CSFP涉及的船只数量的增加而增加。Logistic回归分析显示UAR是CSFP的独立预测因子。受试者工作特征（ROC）曲线分析表明，当UAR大于7.9时，AUC为0.883（95％CI：0.840-0.927，p<0.001），敏感性和特异性分别为78.2%和88.2%。
结论：尿酸与血浆白蛋白联用，UAR可以作为CSFP的独立预测因子。
