Abstract：
Diagnosing a pregnant woman\'s glucose intolerance is referred to as gestational diabetes mellitus (GDM). Diabetes has been linked to enhanced oxidative stress. In this condition, oxidative stress may damage nucleic acids, fats, and proteins, which in turn affects cell and tissue functions. The present study highlights the relationship between oxidative stress and GDM, with a particular focus on the role of hyperglycemia-induced processes during reactive oxygen species (ROS) oversupply, followed by it discusses the oxidative stress biomarkers and assesses the effects of antioxidant supplements on glycemic control, inflammatory processes, and oxidative stress among individuals with GDM. Two reviewers conducted a comprehensive literature search utilizing the PubMed®, Web of Science™, and Scopus® databases. Only items published in the English language up until June 2024 were taken into account. We conducted a thorough search of research databases to identify articles that had the terms \"oxidative stress\" or \"antioxidant\" and \"GDM\". From this search, we selected 55 relevant papers to be included in this narrative review. Pregnancy-induced hypertension, postpartum bleeding, lower birth weight, a higher risk of hyperbilirubinemia in their neonates, fetal growth retardation, and birth asphyxia were revealed to be outcomes of women enduring major oxidative stress during pregnancy. Furthermore, tight glycemic control both before and throughout pregnancy as well as oxidative stress treatment may help women highly prone to GDM.
摘要：
诊断孕妇的葡萄糖不耐受被称为妊娠期糖尿病（GDM）。糖尿病与氧化应激增强有关。在这种情况下,氧化应激可能会损伤核酸，脂肪，和蛋白质，进而影响细胞和组织功能。本研究强调了氧化应激与GDM之间的关系，特别关注高血糖诱导过程在活性氧（ROS）过度供应期间的作用，随后讨论了氧化应激生物标志物，并评估了抗氧化剂补充剂对血糖控制的影响，炎症过程，GDM患者的氧化应激水平。两名审稿人利用PubMed®进行了全面的文献检索，WebofScience™,和Scopus®数据库。仅考虑到2024年6月之前以英语发布的项目。我们对研究数据库进行了彻底的搜索，以确定有术语“氧化应激”或“抗氧化剂”和“GDM”的文章。从这次搜索中，我们选择了55篇相关论文纳入这篇叙述性综述。妊娠高血压,产后出血,降低出生体重,新生儿高胆红素血症的风险更高，胎儿生长迟缓,出生窒息是女性在怀孕期间承受主要氧化应激的结局。此外，妊娠前和整个妊娠期间的严格血糖控制以及氧化应激治疗可能有助于极易发生GDM的女性.
