Abstract：
BACKGROUND: The Patient Acceptable Symptoms State (PASS) is a validated instrument that is used to assess whether a patient with psoriatic arthritis (PsA) accepts her/his disease status by asking them a simple question: \"Think about all the ways your PsA has affected you during the last 48 h. If you were to remain in the next few months as you were during the last 48 h, would this be acceptable to you?\" The aim of the present study was to explore any PASS differences in patients with PsA based on sex by looking at the corresponding thresholds of Disease Activity for Psoriatic Arthritis (DAPSA), Psoriatic Arthritis Impact of the Disease-12 (PsAID-12) and the Health Assessment Questionnaire-Disability Index (HAQ-DI) in female and male patients.
METHODS: This was a cross-sectional study that included two PsA cohorts. To identify the DAPSA, PsAID and HAQ-DI thresholds that differentiated patients who reported \"yes\" in response to the PASS question from those who reported \"no,\" we used the receiver operating characteristic curves both for the female and male sexes. Moreover, Cohen\'s kappa test was used to determine the agreement of a PASS \"yes\" with DAPSA ≤ 14, PsAID ≤ 4 and HAQ-DI ≤ 0.5.
RESULTS: Three-hundred ten patients were considered for the study. The DAPSA, PsAID-12 and HAQ-DI thresholds that differentiated PASS \"yes\" patients from PASS \"no\" patients were 11.7, 1.85 and 0.625 in male patients and 13.3, 3.85 and 0.750 in female patients, respectively. A PASS \"yes\" and DAPSA ≤ 14 showed moderate agreement in males (kappa = 0.56) and good agreement in females (kappa = 0.80); the agreement between a PASS \"yes\" and PsAID ≤ 4 and between a PASS \"yes\" and HAQ-DI ≤ 0.5 was higher in female patients (moderate).
CONCLUSIONS: Female patients accept their disease at higher DAPSA, PsAID and HAQ-DI values than male patients do. The clinical meaning of this could be that a female patient generally has a greater global disease acceptance inclination. Therefore, this study further supports the concept that sex differences are present in patients with PsA.
METHODS: This was a cross-sectional study that included two PsA cohorts. To identify the DAPSA, PsAID and HAQ-DI thresholds that differentiated patients who reported \"yes\" in response to the PASS question from those who reported \"no,\" we used the receiver operating characteristic curves both for the female and male sexes. Moreover, Cohen\'s kappa test was used to determine the agreement of a PASS \"yes\" with DAPSA ≤ 14, PsAID ≤ 4 and HAQ-DI ≤ 0.5.
RESULTS: Three-hundred ten patients were considered for the study. The DAPSA, PsAID-12 and HAQ-DI thresholds that differentiated PASS \"yes\" patients from PASS \"no\" patients were 11.7, 1.85 and 0.625 in male patients and 13.3, 3.85 and 0.750 in female patients, respectively. A PASS \"yes\" and DAPSA ≤ 14 showed moderate agreement in males (kappa = 0.56) and good agreement in females (kappa = 0.80); the agreement between a PASS \"yes\" and PsAID ≤ 4 and between a PASS \"yes\" and HAQ-DI ≤ 0.5 was higher in female patients (moderate).
CONCLUSIONS: Female patients accept their disease at higher DAPSA, PsAID and HAQ-DI values than male patients do. The clinical meaning of this could be that a female patient generally has a greater global disease acceptance inclination. Therefore, this study further supports the concept that sex differences are present in patients with PsA.
摘要：
背景：患者可接受症状状态（PASS）是一种经过验证的工具，用于评估患有银屑病关节炎（PsA）的患者是否接受了她/他的疾病状态，问他们一个简单的问题：这对你来说是可以接受的吗？“本研究的目的是通过查看银屑病关节炎（DAPSA）的疾病活动的相应阈值来探索PsA患者的任何PASS差异，Psoriatic关节炎对女性和男性患者的疾病-12（PsAID-12）和健康评估问卷-残疾指数（HAQ-DI）的影响。
方法：这是一项横断面研究，包括两个PsA队列。为了识别DAPSA，PsAID和HAQ-DI阈值可区分对PASS问题报告“是”的患者与报告“否”的患者，“我们使用了女性和男性的接受者工作特征曲线。此外，Cohen的kappa检验用于确定PASS“是”与DAPSA≤14，PsAID≤4和HAQ-DI≤0.5的一致性。
结果：本研究考虑了三百十例患者。DAPSA,PsAID-12和HAQ-DI区分PASS“是”患者与PASS“否”患者的阈值在男性患者中为11.7、1.85和0.625，在女性患者中为13.3、3.85和0.750，分别。PASS“是”和DAPSA≤14在男性中显示中等一致性（kappa=0.56），在女性中显示良好一致性（kappa=0.80）；女性患者（中度）的PASS“是”与PsAID≤4之间以及PASS“是”与HAQ-DI≤0.5之间的一致性较高。
结论：女性患者接受较高DAPSA的疾病，PsAID和HAQ-DI值优于男性患者。其临床意义可能是女性患者通常具有更大的全球疾病接受倾向。因此,这项研究进一步支持了PsA患者存在性别差异的观点.
方法：这是一项横断面研究，包括两个PsA队列。为了识别DAPSA，PsAID和HAQ-DI阈值可区分对PASS问题报告“是”的患者与报告“否”的患者，“我们使用了女性和男性的接受者工作特征曲线。此外，Cohen的kappa检验用于确定PASS“是”与DAPSA≤14，PsAID≤4和HAQ-DI≤0.5的一致性。
结果：本研究考虑了三百十例患者。DAPSA,PsAID-12和HAQ-DI区分PASS“是”患者与PASS“否”患者的阈值在男性患者中为11.7、1.85和0.625，在女性患者中为13.3、3.85和0.750，分别。PASS“是”和DAPSA≤14在男性中显示中等一致性（kappa=0.56），在女性中显示良好一致性（kappa=0.80）；女性患者（中度）的PASS“是”与PsAID≤4之间以及PASS“是”与HAQ-DI≤0.5之间的一致性较高。
结论：女性患者接受较高DAPSA的疾病，PsAID和HAQ-DI值优于男性患者。其临床意义可能是女性患者通常具有更大的全球疾病接受倾向。因此,这项研究进一步支持了PsA患者存在性别差异的观点.
