PDF(Pubmed)
Abstract：
In this research, the magnetic solid acid nanocatalyst based on ferrierite has been prepared and used as catalyst for the green synthesis of some [1,3]-oxazine derivatives in water at room temperature. The synthesized compounds were obtained in high to excellent yields after short reaction times and the structure of synthesized products were investigated by spectroscopic methods such as: FT-IR, 1H NMR and 13C NMR. The prepared magnetic solid acid catalyst was characterized using XRD, FT-IR, FE-SEM, EDX, elemental mapping, TGA and VSM analysis methods. Magnetic catalyst has easy separation ability, which leads to better and easier recycling. The preparation and synthesis of [1,3]-oxazine derivatives were carried out at room temperature in the presence of M-FER/TEPA/SO3H. Easy workup, green solvent (water) and also short reaction times with high to excellent yield of products, are some of advantageous of presented method. Docking calculations on the structure of the synthesized compounds proved their medicinal properties against breast cancer cells.
摘要：
在这项研究中,制备了基于镁碱沸石的磁性固体酸纳米催化剂，并将其用作室温在水中绿色合成某些[1,3]-恶嗪衍生物的催化剂。合成的化合物在短的反应时间后以高至优异的产率获得，合成产物的结构通过光谱方法如：FT-IR，1HNMR和13CNMR。利用XRD对制备的磁性固体酸催化剂进行了表征,FT-IR,FE-SEM，EDX,元素映射,TGA和VSM分析方法。磁性催化剂具有易于分离的能力，这导致更好和更容易的回收。[1,3]-恶嗪衍生物的制备和合成在室温下在M-FER/TEPA/SO3H存在下进行。简单的工作，绿色溶剂（水），反应时间短，产品产率高，是所提出方法的一些优点。对合成化合物结构的对接计算证明了它们对乳腺癌细胞的药用特性。
