Abstract：
BACKGROUND: Sarcopenia, defined as progressive and generalised loss of skeletal muscle mass, quality, and strength, is considered as a poor prognostic factor in cancer. Outcomes in oncology mainly focus on survival related to disease and treatment. Other factors affecting the end result get less attention. This study was conducted with the aim to determine presence of sarcopenia in operable gastric cancer, factors positively correlating with presence of sarcopenia and its impact on early postoperative outcomes.
METHODS: This is a prospective study conducted from January 2020 to December 2021 in a tertiary care cancer hospital. All patients with adenocarcinoma stomach planned for curative intent surgery were assessed for sarcopenia by measuring hand grip strength(HGS) and skeletal muscle index(SMI). Comparison was made between patient and tumour related factors in patients with and without sarcopenia and impact of sarcopenia on early postoperative outcome was assessed.
RESULTS: 74 patients were assessed for sarcopenia. 32 (43.2 %) were patients diagnosed with sarcopenia. Advanced age(p = 0.040), low BMI (p < 0.001), gastric outlet obstruction (p = 0.020) and urgent surgery (p = 0.002) positively correlated with sarcopenia. Curative resection was done in 68(91.89 %) patients and these patients were evaluated for early postoperative outcomes. 18 (26.5 %) patients had complications of Clavien Dindo grade 3 or above. Sarcopenia was not significantly associated with major postoperative complications(p = 0.857).
CONCLUSIONS: Sarcopenia, though associated with a substantial proportion of patients with gastric cancer, does not significantly affect early postoperative complications in a high volume oncology centre .
METHODS: This is a prospective study conducted from January 2020 to December 2021 in a tertiary care cancer hospital. All patients with adenocarcinoma stomach planned for curative intent surgery were assessed for sarcopenia by measuring hand grip strength(HGS) and skeletal muscle index(SMI). Comparison was made between patient and tumour related factors in patients with and without sarcopenia and impact of sarcopenia on early postoperative outcome was assessed.
RESULTS: 74 patients were assessed for sarcopenia. 32 (43.2 %) were patients diagnosed with sarcopenia. Advanced age(p = 0.040), low BMI (p < 0.001), gastric outlet obstruction (p = 0.020) and urgent surgery (p = 0.002) positively correlated with sarcopenia. Curative resection was done in 68(91.89 %) patients and these patients were evaluated for early postoperative outcomes. 18 (26.5 %) patients had complications of Clavien Dindo grade 3 or above. Sarcopenia was not significantly associated with major postoperative complications(p = 0.857).
CONCLUSIONS: Sarcopenia, though associated with a substantial proportion of patients with gastric cancer, does not significantly affect early postoperative complications in a high volume oncology centre .
摘要：
背景：肌肉减少症，定义为骨骼肌质量的进行性和广泛性损失，质量,和力量，被认为是癌症预后不良的因素。肿瘤学的结果主要集中在与疾病和治疗相关的生存。影响最终结果的其他因素较少受到关注。这项研究的目的是确定可手术胃癌中肌肉减少症的存在。与肌肉减少症的存在呈正相关的因素及其对术后早期结局的影响。
方法：这是一项前瞻性研究，于2020年1月至2021年12月在一家三级癌症医院进行。通过测量手握力（HGS）和骨骼肌指数（SMI）评估所有计划进行根治性手术的腺癌胃患者的肌肉减少症。比较有无少肌症患者的患者和肿瘤相关因素，并评估少肌症对术后早期预后的影响。
结果：对74例患者进行了肌少症评估。32例（43.2％）被诊断为肌肉减少症。高龄（p=0.040），低BMI（p<0.001），胃出口梗阻(p=0.020)和紧急手术(p=0.002)与肌少症呈正相关。对68例（91.89%）患者进行了根治性切除，并对这些患者的术后早期结果进行了评估。18例（26.5％）患者出现ClavienDindo3级或以上并发症。肌肉减少症与术后主要并发症无显著相关性(p=0.857)。
结论：肌肉减少症，尽管与相当大比例的胃癌患者有关，对高容量肿瘤中心的早期术后并发症没有显著影响。
方法：这是一项前瞻性研究，于2020年1月至2021年12月在一家三级癌症医院进行。通过测量手握力（HGS）和骨骼肌指数（SMI）评估所有计划进行根治性手术的腺癌胃患者的肌肉减少症。比较有无少肌症患者的患者和肿瘤相关因素，并评估少肌症对术后早期预后的影响。
结果：对74例患者进行了肌少症评估。32例（43.2％）被诊断为肌肉减少症。高龄（p=0.040），低BMI（p<0.001），胃出口梗阻(p=0.020)和紧急手术(p=0.002)与肌少症呈正相关。对68例（91.89%）患者进行了根治性切除，并对这些患者的术后早期结果进行了评估。18例（26.5％）患者出现ClavienDindo3级或以上并发症。肌肉减少症与术后主要并发症无显著相关性(p=0.857)。
结论：肌肉减少症，尽管与相当大比例的胃癌患者有关，对高容量肿瘤中心的早期术后并发症没有显著影响。
