Abstract：
BACKGROUND: Delta-9-tetraydrocannabinol (THC) usage is associated with venous thromboembolic events (VTE) in trauma patients. We hypothesized that THC + trauma patients would have less platelet inhibition than THC - patients using thromboelastography with platelet mapping (TEG-PM).
METHODS: Results from initial TEG- PM assays and patient\'s UDS were reviewed between 2019 and 2023. Mean levels of arachidonic acid (AA) and adenosine diphosphate (ADP) percent inhibition were compared by THC status.
RESULTS: 793 patients had TEG-PM and UDS data. Mean levels of arachidonic acid (AA) percentage inhibition were 32.6 ± 34.2. AA inhibition was lower for THC + vs THC- patients (THC+ 23.9 ± 27.0 vs THC- 34.3 ± 35.3, P < 0.001). There was no association between THC status and ADP inhibition (THC+ 32.5 ± 27.1 vs THC- 30.8 ± 28.4, P = 0.536).
CONCLUSIONS: To our knowledge, our data are the first to suggest a clinically measurable increase in platelet reactivity in THC + trauma patients. More work is needed to determine if addition of aspirin to the chemoprophylaxis strategy for THC + patients would mitigate the known association of THC with VTE.
METHODS: Results from initial TEG- PM assays and patient\'s UDS were reviewed between 2019 and 2023. Mean levels of arachidonic acid (AA) and adenosine diphosphate (ADP) percent inhibition were compared by THC status.
RESULTS: 793 patients had TEG-PM and UDS data. Mean levels of arachidonic acid (AA) percentage inhibition were 32.6 ± 34.2. AA inhibition was lower for THC + vs THC- patients (THC+ 23.9 ± 27.0 vs THC- 34.3 ± 35.3, P < 0.001). There was no association between THC status and ADP inhibition (THC+ 32.5 ± 27.1 vs THC- 30.8 ± 28.4, P = 0.536).
CONCLUSIONS: To our knowledge, our data are the first to suggest a clinically measurable increase in platelet reactivity in THC + trauma patients. More work is needed to determine if addition of aspirin to the chemoprophylaxis strategy for THC + patients would mitigate the known association of THC with VTE.
摘要：
背景：Delta-9-四羟基大麻酚（THC）的使用与创伤患者的静脉血栓栓塞事件（VTE）相关。我们假设THC+创伤患者的血小板抑制比THC-使用血小板定位血栓弹力图（TEG-PM）的患者少。
方法：回顾了2019年至2023年初始TEG-PM测定和患者UDS的结果。通过THC状态比较花生四烯酸（AA）和二磷酸腺苷（ADP）抑制百分比的平均水平。
结果：793例患者有TEG-PM和UDS数据。花生四烯酸（AA）抑制百分比的平均水平为32.6±34.2。THC+和THC-患者的AA抑制作用较低（THC+23.9±27.0vsTHC-34.3±35.3，P<0.001）。THC状态与ADP抑制之间没有关联（THC+32.5±27.1vsTHC-30.8±28.4，P=0.536）。
结论：据我们所知，我们的数据首次表明THC+创伤患者的血小板反应性增加。需要更多的工作来确定在THC+患者的化学预防策略中添加阿司匹林是否会减轻已知的THC与VTE的关联。
方法：回顾了2019年至2023年初始TEG-PM测定和患者UDS的结果。通过THC状态比较花生四烯酸（AA）和二磷酸腺苷（ADP）抑制百分比的平均水平。
结果：793例患者有TEG-PM和UDS数据。花生四烯酸（AA）抑制百分比的平均水平为32.6±34.2。THC+和THC-患者的AA抑制作用较低（THC+23.9±27.0vsTHC-34.3±35.3，P<0.001）。THC状态与ADP抑制之间没有关联（THC+32.5±27.1vsTHC-30.8±28.4，P=0.536）。
结论：据我们所知，我们的数据首次表明THC+创伤患者的血小板反应性增加。需要更多的工作来确定在THC+患者的化学预防策略中添加阿司匹林是否会减轻已知的THC与VTE的关联。
