Abstract：
OBJECTIVE: To measure the choroidal circulatory parameters Han Chinese children aged 4-14 years from Southwest China, and to explore the relationships between these parameters and age, axial length (AL), and choroidal thickness (ChT).
METHODS: 284 eyes from 142 subjects were included in this cross-sectional study. All participants underwent cycloplegic refraction and IOLMaster500 examination. Swept-source optical coherence tomography (SS-OCT) was used to measure submacular choroidal thickness, choroidal vascular volume (CVV), choroidal stromal volume (CSV), choroidal vascularity index (CVI), and CVV/CSV ratio.
RESULTS: In this population, the mean CVV was 2.92 ± 0.55 mm3, CSV was 4.69 ± 0.68 mm3, CVI was 38.22 ± 2.46 %, and CVV/CSV ratio was 62.11 ± 6.44 %. Multivariable regression analyses showed that both CVV and CSV were negatively correlated with AL (both P < 0.001) and positively correlated with ChT (both P < 0.001), while age showed no significant correlation with them (both P > 0.05). However, the correlations between CVI and age were not uniform rectilinear. Among participants aged ≤8 years, CVI showed no correlation with age (P > 0.05), while among those aged >8 years, it was positively correlated with age (P < 0.01). CVV/CSV ratio was positively correlated with ChT and age (both P < 0.01).
CONCLUSIONS: After the age of 8, age was positively correlated with CVI. ChT was well correlated with CVI. Longer AL and thinner ChT were associated with reduced CVV and CSV, with CVV decreasing more rapidly than CSV.
METHODS: 284 eyes from 142 subjects were included in this cross-sectional study. All participants underwent cycloplegic refraction and IOLMaster500 examination. Swept-source optical coherence tomography (SS-OCT) was used to measure submacular choroidal thickness, choroidal vascular volume (CVV), choroidal stromal volume (CSV), choroidal vascularity index (CVI), and CVV/CSV ratio.
RESULTS: In this population, the mean CVV was 2.92 ± 0.55 mm3, CSV was 4.69 ± 0.68 mm3, CVI was 38.22 ± 2.46 %, and CVV/CSV ratio was 62.11 ± 6.44 %. Multivariable regression analyses showed that both CVV and CSV were negatively correlated with AL (both P < 0.001) and positively correlated with ChT (both P < 0.001), while age showed no significant correlation with them (both P > 0.05). However, the correlations between CVI and age were not uniform rectilinear. Among participants aged ≤8 years, CVI showed no correlation with age (P > 0.05), while among those aged >8 years, it was positively correlated with age (P < 0.01). CVV/CSV ratio was positively correlated with ChT and age (both P < 0.01).
CONCLUSIONS: After the age of 8, age was positively correlated with CVI. ChT was well correlated with CVI. Longer AL and thinner ChT were associated with reduced CVV and CSV, with CVV decreasing more rapidly than CSV.
摘要：
目的：测量中国西南地区4-14岁汉族儿童的脉络膜循环参数，并探索这些参数与年龄之间的关系，轴向长度（AL），和脉络膜厚度（ChT）。
方法：本横断面研究包括142名受试者的284只眼。所有参与者都接受了睫状肌麻痹屈光和IOLMaster500检查。扫描源光学相干断层扫描（SS-OCT）用于测量黄斑下脉络膜厚度，脉络膜血管容积(CVV),脉络膜基质体积（CSV），脉络膜血管分布指数(CVI),和CVV/CSV比率。
结果：在这个人群中，平均CVV为2.92±0.55mm3，CSV为4.69±0.68mm3，CVI为38.22±2.46%，CVV/CSV比值为62.11±6.44%。多因素回归分析显示,CVV和CSV均与AL呈负相关(均P<0.001),与ChT呈正相关(均P<0.001)。年龄与两者无显著相关性(均P>0.05)。然而,CVI与年龄之间的相关性不是一致的直线关系。在年龄≤8岁的参与者中，CVI与年龄无相关性(P>0.05),而在年龄>8岁的人群中，与年龄呈正相关(P<0.01)。CVV/CSV比值与ChT、年龄呈正相关(均P<0.01)。
结论：8岁后，年龄与CVI呈正相关。ChT与CVI有很好的相关性。较长的AL和较薄的ChT与CVV和CSV减少有关，CVV比CSV下降得更快。
方法：本横断面研究包括142名受试者的284只眼。所有参与者都接受了睫状肌麻痹屈光和IOLMaster500检查。扫描源光学相干断层扫描（SS-OCT）用于测量黄斑下脉络膜厚度，脉络膜血管容积(CVV),脉络膜基质体积（CSV），脉络膜血管分布指数(CVI),和CVV/CSV比率。
结果：在这个人群中，平均CVV为2.92±0.55mm3，CSV为4.69±0.68mm3，CVI为38.22±2.46%，CVV/CSV比值为62.11±6.44%。多因素回归分析显示,CVV和CSV均与AL呈负相关(均P<0.001),与ChT呈正相关(均P<0.001)。年龄与两者无显著相关性(均P>0.05)。然而,CVI与年龄之间的相关性不是一致的直线关系。在年龄≤8岁的参与者中，CVI与年龄无相关性(P>0.05),而在年龄>8岁的人群中，与年龄呈正相关(P<0.01)。CVV/CSV比值与ChT、年龄呈正相关(均P<0.01)。
结论：8岁后，年龄与CVI呈正相关。ChT与CVI有很好的相关性。较长的AL和较薄的ChT与CVV和CSV减少有关，CVV比CSV下降得更快。
