Abstract：
Autoimmunity is a normal physiological state that requires immunological homeostasis and surveillance, whereas necroptosis is a type of inflammatory cell death. When necroptosis occurs, various immune system cells must perform their appropriate duties to preserve immunological homeostasis, whether the consequence is expanding or limiting the inflammatory response and the pathological condition is cleared or progresses to the autoimmune disease stage. This article discusses necroptosis based on RIP homotypic interaction motif (RHIM) interaction under various physiological and pathological situations, with the RIPK1-RIPK3-MLKL necrosome serving as the regulatory core. In addition, the cell biology of necroptosis involved in autoimmunity and its application in autoimmune diseases were also reviewed.
摘要：
自身免疫是一种正常的生理状态，需要免疫稳态和监测，而坏死是一种炎性细胞死亡。当坏死发生时，各种免疫系统细胞必须履行其适当的职责，以保持免疫稳态，无论结果是扩大或限制炎症反应和病理状况被清除或进展到自身免疫性疾病阶段。本文讨论了在各种生理和病理情况下基于RIP同型相互作用基序（RHIM）相互作用的坏死，以RIPK1-RIPK3-MLKL为调控核心。此外,本文还对参与自身免疫的坏死细胞生物学及其在自身免疫性疾病中的应用进行了综述。
