关键词: Photodynamic therapy antimicrobial photodynamic therapy cancer combination therapy

Mesh : Photochemotherapy / methods Humans Neoplasms / drug therapy Animals Photosensitizing Agents / therapeutic use

来  源:   DOI:10.1016/j.drudis.2024.104099

Abstract:
Photodynamic therapy (PDT) is a minimally invasive treatment showing promise against cancer and microbial infections. PDT targets tumor cells while sparing healthy tissue, reducing side effects. It induces immunogenic cell death, potentially stimulating antitumor immune responses and reducing cancer recurrence. In microbial treatment, PDT effectively combats bacteria, fungi and viruses. Combining PDT with chemotherapy, radiotherapy and immunotherapy enhances its efficacy. However, challenges such as tumor hypoxia, limited tissue penetration and phototoxicity necessitate ongoing research efforts to optimize PDT protocols and overcome limitations. Overall, PDT is versatile and continually advancing with refined protocols to improve its clinical utility against cancer and microbial infections.
摘要:
光动力疗法(PDT)是一种微创治疗,显示出对抗癌症和微生物感染的希望。PDT靶向肿瘤细胞,同时保留健康组织,减少副作用。它诱导免疫原性细胞死亡,潜在的刺激抗肿瘤免疫反应和减少癌症复发。在微生物处理中,PDT有效对抗细菌,真菌和病毒。PDT联合化疗,放疗和免疫治疗可增强其疗效。然而,挑战如肿瘤缺氧,有限的组织穿透性和光毒性需要持续的研究努力来优化PDT方案并克服局限性.总的来说,PDT是多才多艺的,并以完善的方案不断推进,以提高其对抗癌症和微生物感染的临床效用。
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