Abstract：
BACKGROUND: Infectious diseases remain a major global health concern, including in China, with an estimated >10 million cases of infectious disease in 2019. We describe the burden of site-specific infectious diseases among Chinese adults.
METHODS: From 2004 to 2008, the prospective China Kadoorie Biobank enrolled 512,726 adults aged 30-79 years from 10 diverse areas (5 rural, 5 urban) of China. During the 12 years of follow-up, 101,673 participants were hospitalized for any infectious disease. Descriptive analyses examined standardized incidence, mortality and case fatality of infections.
RESULTS: The incidence of any infectious disease was 1856 per 100,000 person-years; respiratory tract infections (1069) were most common. The infectious disease mortality rate was 31.8 per 100,000 person-years (20.3 and 9.4 for respiratory and non-respiratory infections, respectively) and case fatality was 2.2% (2.6% and 1.6% for respiratory and non-respiratory infections, respectively). Infectious disease incidence and mortality rates were higher at older ages and in rural areas. There were no clear sex differences in infectious disease incidence rates, but mortality and case fatality rates were twice as high in men as in women.
CONCLUSIONS: Infectious diseases were common in Chinese adults. The observed burden of, and disparities in, site-specific infections can inform targeted prevention efforts.
BACKGROUND: Kadoorie Foundation, Wellcome Trust, MRC, BHF, CR-UK, MoST, NNSF.
METHODS: From 2004 to 2008, the prospective China Kadoorie Biobank enrolled 512,726 adults aged 30-79 years from 10 diverse areas (5 rural, 5 urban) of China. During the 12 years of follow-up, 101,673 participants were hospitalized for any infectious disease. Descriptive analyses examined standardized incidence, mortality and case fatality of infections.
RESULTS: The incidence of any infectious disease was 1856 per 100,000 person-years; respiratory tract infections (1069) were most common. The infectious disease mortality rate was 31.8 per 100,000 person-years (20.3 and 9.4 for respiratory and non-respiratory infections, respectively) and case fatality was 2.2% (2.6% and 1.6% for respiratory and non-respiratory infections, respectively). Infectious disease incidence and mortality rates were higher at older ages and in rural areas. There were no clear sex differences in infectious disease incidence rates, but mortality and case fatality rates were twice as high in men as in women.
CONCLUSIONS: Infectious diseases were common in Chinese adults. The observed burden of, and disparities in, site-specific infections can inform targeted prevention efforts.
BACKGROUND: Kadoorie Foundation, Wellcome Trust, MRC, BHF, CR-UK, MoST, NNSF.
摘要：
背景：传染病仍然是全球主要的健康问题，包括在中国,2019年估计有超过1000万的传染病病例。我们描述了中国成年人中特定部位传染病的负担。
方法：从2004年到2008年，前瞻性中国嘉道理生物库从10个不同地区招募了512,726名30-79岁的成年人（5个农村，5城市）中国。在12年的随访中，101,673名参与者因任何传染病住院。描述性分析检查了标准化发生率，死亡率,和感染的病死率。
结果：任何传染病的发病率为每100,000人年1856；呼吸道感染（1069）是最常见的。传染病死亡率为31.8/10万人年(呼吸道和非呼吸道感染分别为20.3和9.4,分别）和病死率为2.2％（呼吸道和非呼吸道感染分别为2.6％和1.6％，分别)。老年人和农村地区的传染病发病率和死亡率较高。传染病发病率没有明显的性别差异，但是男性的死亡率和病死率是女性的两倍。
结论：传染病在中国成年人中很常见。观察到的负担，和差距，特定部位的感染可以为有针对性的预防工作提供信息.
背景：嘉道理基金会，惠康信托基金,MRC,BHF,CR-UK,Most,NNSF。
方法：从2004年到2008年，前瞻性中国嘉道理生物库从10个不同地区招募了512,726名30-79岁的成年人（5个农村，5城市）中国。在12年的随访中，101,673名参与者因任何传染病住院。描述性分析检查了标准化发生率，死亡率,和感染的病死率。
结果：任何传染病的发病率为每100,000人年1856；呼吸道感染（1069）是最常见的。传染病死亡率为31.8/10万人年(呼吸道和非呼吸道感染分别为20.3和9.4,分别）和病死率为2.2％（呼吸道和非呼吸道感染分别为2.6％和1.6％，分别)。老年人和农村地区的传染病发病率和死亡率较高。传染病发病率没有明显的性别差异，但是男性的死亡率和病死率是女性的两倍。
结论：传染病在中国成年人中很常见。观察到的负担，和差距，特定部位的感染可以为有针对性的预防工作提供信息.
背景：嘉道理基金会，惠康信托基金,MRC,BHF,CR-UK,Most,NNSF。
