Abstract：
Vitamin A (VA) has many functions in the body, some of which are key for the development and functioning of the nervous system, while some others might indirectly influence neural function. Both hypovitaminosis and hypervitaminosis A can lead to clinical manifestations of concern for individuals and for general global health. Scientific evidence on the link between VA and autism spectrum disorder (ASD) is growing, with some clinical studies and accumulating results obtained from basic research using cellular and animal models. Remarkably, it has been shown that VA deficiency can exacerbate autistic symptomatology. In turn, VA supplementation has been shown to be able to improve autistic symptomatology in selected groups of individuals with ASD. However, it is important to recognize that ASD is a highly heterogeneous condition. Therefore, it is important to clarify how and when VA supplementation can be of benefit for affected individuals. Here we delve into the relationship between VA and ASD, discussing clinical observations and mechanistic insights obtained from research on selected autistic syndromes and laboratory models to advance in defining how the VA signaling pathway can be exploited for treatment of ASD.
摘要：
维生素A（VA）在体内具有许多功能，其中一些是神经系统发育和功能的关键，而其他一些可能间接影响神经功能。维生素缺乏症和维生素缺乏症A均可导致个体和总体全球健康关注的临床表现。关于VA和自闭症谱系障碍（ASD）之间联系的科学证据正在增加，与一些临床研究和积累的结果从基础研究使用细胞和动物模型。值得注意的是,研究表明，VA缺乏会加剧自闭症症状。反过来,已显示补充VA能够改善选定的ASD个体组中的自闭症症状学。然而,重要的是要认识到ASD是一种高度异质性的疾病。因此,重要的是要明确补充VA如何以及何时对受影响的个体有益.在这里，我们深入研究VA和ASD之间的关系，讨论从选定的自闭症综合征和实验室模型的研究中获得的临床观察和机制见解，以进一步定义如何利用VA信号通路治疗ASD。
