Abstract：
Urolithin A (UA) is a gut metabolite derived from ellagic acid. This systematic review assesses the potential geroprotective effect of UA in humans. In five studies including 250 healthy individuals, UA (10-1000 mg/day) for a duration ranging from 28 days to 4 months, showed a dose-dependent anti-inflammatory effect and upregulated some mitochondrial genes, markers of autophagy, and fatty acid oxidation. It did not affect mitochondrial maximal adenosine triphosphate production, biogenesis, dynamics, or gut microbiota composition. UA increased muscle strength and endurance, however, had no effect on anthropometrics, cardiovascular outcomes, and physical function. Unrelated adverse events were mild or moderate. Further research across more physiological systems and longer intervention periods is required.
摘要：
尿石素A(UA)是来源于鞣花酸的肠道代谢产物。这项系统评价评估了UA对人类的潜在保护作用。在包括250名健康个体的五项研究中，UA（10-1000mg/天），持续时间为28天至4个月，显示剂量依赖性抗炎作用，并上调一些线粒体基因，自噬的标志物，和脂肪酸氧化。它不影响线粒体最大三磷酸腺苷的产生，生物发生，动力学,或肠道菌群组成。UA增加肌肉力量和耐力，然而,对人体测量没有影响，心血管结果，和身体功能。不相关的不良事件为轻度或中度。需要对更多的生理系统和更长的干预期进行进一步的研究。
