Abstract：
Cardiorenal syndrome (CRS) is defined as a broad spectrum of conditions encompassing both the heart and kidneys in which acute or chronic heart disorder may induce acute or chronic tubular injury in the kidneys and vice versa. Early diagnosis allows timely intervention and attenuates disease progression. Two well-established biomarkers, neutrophil gelatinase-associated lipocalin (NGAL) and brain (B-type) natriuretic peptide (BNP), are reflective of impaired cardiac and kidney function associated with poor prognosis in various cardiac disorders, including heart failure and coronary artery disease. Given the ongoing contribution of CRS to the high morbidity and mortality post-MI, early risk stratification and preventive measures are highly significant. In this review, we examine Surface Plasmon Resonance (SPR) optical biosensors for detection of these biomarkers and discuss potential implications of this highly sensitive and specific technology in CRS detection, treatment and outcomes.
摘要：
心肾综合征(CRS)被定义为涵盖心脏和肾脏的广谱病症,其中急性或慢性心脏病可在肾脏中诱发急性或慢性肾小管损伤,反之亦然。早期诊断允许及时干预并减轻疾病进展。两个公认的生物标志物，中性粒细胞明胶酶相关脂质运载蛋白（NGAL）和脑（B型）利钠肽（BNP），反映了心脏和肾功能受损与各种心脏疾病的不良预后相关，包括心力衰竭和冠状动脉疾病。鉴于CRS对MI后高发病率和高死亡率的持续贡献，早期风险分层和预防措施非常重要。在这次审查中,我们研究了表面等离子体共振（SPR）光学生物传感器，用于检测这些生物标志物，并讨论了这种高灵敏度和特异性技术在CRS检测中的潜在含义。治疗和结果。
