Abstract：
Bismuth-213 is a radionuclide of interest for targeted alpha therapy and is supplied via a radiochemical generator system through the decay of 225Ac. Radionuclide generators employ longer lived \"parent\" radionuclides to routinely supply shorter-lived \"daughter\" radionuclides. The traditional 225Ac/213Bi radiochemical generator relies on an organic cation exchange resin where 225Ac binds to the resin and 213Bi is routinely eluted. These resins degrade when they absorb large doses of ionizing radiation (>1 × 106 Gy/mg), which has been observed when the loading activity of 225Ac exceeds 2.59*109 Bq (70 mCi). Herein we report the development of an electrochemical generator for the supply of 213Bi that has the potential to overcome this limitation. Bismuth-213 spontaneously electrodeposits onto nickel foils in 0.1 M hydrochloric acid at 70 °C. Using this method, we were able to plate an average of 73 ± 4 % of the 213Bi in solution and obtain a final 213Bi recovery of 65 ± 8 % in 0.1 M citrate pH 4.5 via reverse electrolysis using titanium as the cathode. The recovered 213Bi had an average radiochemical purity of >99.8 % and was successfully used to radiolabel DOTATATE with an average radiochemical yield of 85.1 % (not optimized).
摘要：
铋-213是用于靶向α治疗的感兴趣的放射性核素,并且通过225Ac的衰变经由放射化学发生器系统供应。放射性核素发生器使用寿命较长的“父”放射性核素来常规地提供寿命较短的“子”放射性核素。传统的225Ac/213Bi放射化学发生器依赖于有机阳离子交换树脂,其中225Ac与树脂结合并且213Bi被常规洗脱。这些树脂在吸收大剂量的电离辐射（>1×106Gy/mg）时会降解，当225Ac的负载活性超过2.59*109Bq(70mCi)时观察到。在此，我们报告了用于供应213Bi的电化学发生器的开发，该发生器有可能克服这一限制。铋-213在70℃下在0.1M盐酸中自发电沉积到镍箔上。使用此方法，我们能够在溶液中电镀平均73±4％的213Bi，并通过使用钛作为阴极的反向电解在0.1M柠檬酸盐pH4.5中获得65±8％的最终213Bi回收率。回收的213Bi具有>99.8%的平均放射化学纯度,并成功地用于放射性标记DOTATATE,平均放射化学产率为85.1%(未优化)。
