Abstract：
Breast cancer (BC) is a major public health problem that affects women worldwide. Growing evidence has highlighted the role of miRNA-206 in BC pathogenesis. Changes in its expression have diagnostic and prognostic potential as they are associated with clinicopathological parameters, including lymph node metastasis, overall survival, tumor size, metastatic stage, resistance to chemotherapy, and recurrence. In the present study, we summarized, assessed, and discussed the most recent understanding of the functions of miRNA-206 in BC. Unexpectedly, miRNA-206 was found to control both oncogenic and tumor-suppressive pathways. We also considered corresponding downstream effects and upstream regulators. Finally, we addressed the diagnostic and prognostic value of miRNA-206 and its potential for the development of new therapeutic strategies.
摘要：
乳腺癌（BC）是影响全世界妇女的主要公共卫生问题。越来越多的证据强调了miRNA-206在BC发病机制中的作用。其表达的变化具有诊断和预后潜力，因为它们与临床病理参数相关，包括淋巴结转移,总生存率,肿瘤大小,转移阶段，化疗耐药,和复发。在本研究中,我们总结了,评估,并讨论了对miRNA-206在BC中的功能的最新理解。出乎意料的是,miRNA-206被发现控制致癌和肿瘤抑制途径。我们还考虑了相应的下游影响和上游监管机构。最后,我们讨论了miRNA-206的诊断和预后价值及其在开发新治疗策略方面的潜力.
