Abstract：
The recent acceleration of industrialization and urbanization has brought significant attention to N-(1,3-Dimethylbutyl)-N\'-phenyl-p-phenylenediamine quinone (6-PPDQ), an emerging environmental pollutant from tire wear, due to its long-term effects on the environment and organisms. Recent studies suggest that 6-PPDQ can disrupt neurotransmitter synthesis and release, impact receptor function, and alter signaling pathways, potentially causing oxidative stress, inflammation, and apoptosis. This review investigates the potential neurotoxic effects of prolonged 6-PPDQ exposure, the mechanisms underlying its cytotoxicity, and the associated health risks. We emphasize the need for future research, including precise exposure assessments, identification of individual differences, and development of risk assessments and intervention strategies. This article provides a comprehensive overview of 6-PPDQ\'s behavior, impact, and neurotoxicity in the environment, highlighting key areas and challenges for future research.
摘要：
最近工业化和城市化的加速引起了对N-（1,3-二甲基丁基）-N'-苯基-对苯二胺醌（6-PPDQ）的极大关注，一种来自轮胎磨损的新兴环境污染物，由于其对环境和生物的长期影响。最近的研究表明，6-PPDQ可以破坏神经递质的合成和释放，影响受体功能，并改变信号通路，可能导致氧化应激，炎症,和凋亡。这篇综述调查了延长6-PPDQ暴露的潜在神经毒性作用，其细胞毒性的潜在机制，以及相关的健康风险。我们强调未来研究的必要性，包括精确的暴露评估，识别个体差异，并制定风险评估和干预策略。本文全面概述了6-PPDQ的行为，影响，和环境中的神经毒性，强调未来研究的关键领域和挑战。
