Abstract：
There is growing interest in developing diamond electrodes with defined geometries such as, for example, micrometer-sized electrode arrays to acquire signals for electroanalysis. For electroanalytical sensing applications, it is essential to achieve precise conductive patterns on the insulating surface. This work provides a novel approach to boron-doped diamond patterning using nichrome masking for selective seeding on an oxidized silicon substrate. The optimized process involves nichrome deposition, sonication, chemical etching, seeding, and tailored chemical vapor deposition of boron-doped diamond with an intrinsic layer to suppress boron diffusion. Through a systematic investigation, it was determined that isolated boron-doped diamond band electrodes can be efficiently produced on non-conductive silica. Additionally, the influence of boron doping on electrochemical performance was studied, with higher doping enhancing the electrochemical response of band electrodes. To demonstrate sensing capabilities, boron-doped diamond bands were used to detect posaconazole, an antifungal drug, exploiting its electroactive behaviour. A linear correlation between posaconazole concentration and oxidation peak current was observed over 1.43 × 10-8 - 5.71 × 10-6 M with a 1.4 × 10-8 M detection limit. The developed boron-doped diamond microbands could significantly impact the field of electroanalysis, facilitating detection of diverse biologically relevant molecules. Overall, this diamond patterning approach overcomes major challenges towards all-diamond electrochemical sensor chips.
摘要：
人们对开发具有定义几何形状的金刚石电极越来越感兴趣，例如，例如,微米大小的电极阵列，以获取用于电分析的信号。对于电分析传感应用，必须在绝缘表面上实现精确的导电图案。这项工作提供了一种使用镍铬合金掩模在氧化硅衬底上选择性引晶的硼掺杂金刚石图案化的新方法。优化的过程涉及镍铬合金沉积，超声处理，化学蚀刻,播种,以及定制的具有本征层的硼掺杂金刚石的化学气相沉积以抑制硼扩散。通过系统的调查,已确定，可以在非导电二氧化硅上有效地生产隔离的掺硼金刚石带电极。此外,研究了硼掺杂对电化学性能的影响,较高的掺杂提高了带状电极的电化学响应。为了演示传感功能，硼掺杂的金刚石带用于检测泊沙康唑，一种抗真菌药物,利用其电活性行为。在1.43×10-8-5.71×10-6M上观察到泊沙康唑浓度与氧化峰电流之间的线性关系，检出限为1.4×10-8M。开发的掺硼金刚石微带可以显着影响电分析领域，促进多种生物相关分子的检测。总的来说,这种金刚石图案化方法克服了全金刚石电化学传感器芯片的主要挑战。
