Abstract：
OBJECTIVE: To determinate the association between of albumin, neutrophil-lymphocyte ratio and lymphocytes (NLR) with clinical stage in cervical cancers.
METHODS: Design a retrospective cross-sectional study of consecutive subjects diagnosed with cervical cancer for the first time. The Bethesda system was used for histological diagnosis and the subjects were stratified with the FIGO system, considering stages IA to IIB as localized; while, IIIA and IVB as advanced stages. Albumin, NLR and lymphocytes were evaluated as inflammatory biomarkers and the cut-off points generated by the ROC curves were albumin < 3 mg/dL, NLR ≥ 2.0 and lymphocytes < 1.2 103/ul. The association was calculated by Odds Ratios (OR) with 95% confidence intervals.
RESULTS: A total of 152 patients were analyzed, with mean age of 49.3 ± 14.0 years. Epidermoid cancer was the most frequent in 70.6% and 51.3% were classified as advanced clinical stages. A bivariate analysis showed significant relationships between advanced clinical stages and albumin < 3 mg/dL with OR 5.72 (CI95% 2.62-12.4; p < 0.001); for NLR ≥ 2.0 an OR 2.53 (CI95% 1.34-4.89; p = 0.005) and for lymphocytes < 1.2 103/ul of OR 3.39 (CI95% = 1.73-6.65; p < 0.001).
CONCLUSIONS: Albumin levels < 3 mg/dL, NLR ≥ 2.0 and lymphocytes < 1.2 103/ul, were associated with advanced stages in subjects with cervical cancer.
METHODS: Design a retrospective cross-sectional study of consecutive subjects diagnosed with cervical cancer for the first time. The Bethesda system was used for histological diagnosis and the subjects were stratified with the FIGO system, considering stages IA to IIB as localized; while, IIIA and IVB as advanced stages. Albumin, NLR and lymphocytes were evaluated as inflammatory biomarkers and the cut-off points generated by the ROC curves were albumin < 3 mg/dL, NLR ≥ 2.0 and lymphocytes < 1.2 103/ul. The association was calculated by Odds Ratios (OR) with 95% confidence intervals.
RESULTS: A total of 152 patients were analyzed, with mean age of 49.3 ± 14.0 years. Epidermoid cancer was the most frequent in 70.6% and 51.3% were classified as advanced clinical stages. A bivariate analysis showed significant relationships between advanced clinical stages and albumin < 3 mg/dL with OR 5.72 (CI95% 2.62-12.4; p < 0.001); for NLR ≥ 2.0 an OR 2.53 (CI95% 1.34-4.89; p = 0.005) and for lymphocytes < 1.2 103/ul of OR 3.39 (CI95% = 1.73-6.65; p < 0.001).
CONCLUSIONS: Albumin levels < 3 mg/dL, NLR ≥ 2.0 and lymphocytes < 1.2 103/ul, were associated with advanced stages in subjects with cervical cancer.
摘要：
目的：确定白蛋白，中性粒细胞-淋巴细胞比率和淋巴细胞（NLR）与宫颈癌的临床分期。
方法：设计首次诊断为宫颈癌的连续受试者的回顾性横断面研究。Bethesda系统用于组织学诊断，受试者用FIGO系统分层，将IA至IIB阶段视为本地化；而，IIIA和IVB为高级阶段。白蛋白,NLR和淋巴细胞被评估为炎症生物标志物，ROC曲线产生的截止点是白蛋白<3mg/dL，NLR≥2.0，淋巴细胞<1.2103/ul。该关联由具有95%置信区间的赔率比(OR)计算。
结果：共分析了152例患者，平均年龄49.3±14.0岁。表皮样癌在70.6%中最常见，51.3%被归类为晚期临床阶段。双变量分析表明，晚期临床分期与白蛋白<3mg/dL之间存在显着关系，OR为5.72（CI95％2.62-12.4；p<0.001）；对于NLR≥2.0，OR为2.53（CI95％1.34-4.89；p=0.005），对于淋巴细胞<1.2103/ul，OR为3.39（CI95％=1.73-6.65；p<0.001）。
结论：白蛋白水平<3mg/dL，NLR≥2.0，淋巴细胞<1.2103/ul，与宫颈癌患者的晚期相关。
方法：设计首次诊断为宫颈癌的连续受试者的回顾性横断面研究。Bethesda系统用于组织学诊断，受试者用FIGO系统分层，将IA至IIB阶段视为本地化；而，IIIA和IVB为高级阶段。白蛋白,NLR和淋巴细胞被评估为炎症生物标志物，ROC曲线产生的截止点是白蛋白<3mg/dL，NLR≥2.0，淋巴细胞<1.2103/ul。该关联由具有95%置信区间的赔率比(OR)计算。
结果：共分析了152例患者，平均年龄49.3±14.0岁。表皮样癌在70.6%中最常见，51.3%被归类为晚期临床阶段。双变量分析表明，晚期临床分期与白蛋白<3mg/dL之间存在显着关系，OR为5.72（CI95％2.62-12.4；p<0.001）；对于NLR≥2.0，OR为2.53（CI95％1.34-4.89；p=0.005），对于淋巴细胞<1.2103/ul，OR为3.39（CI95％=1.73-6.65；p<0.001）。
结论：白蛋白水平<3mg/dL，NLR≥2.0，淋巴细胞<1.2103/ul，与宫颈癌患者的晚期相关。
