关键词: Cancer survivors Cardio-oncology Cardiovascular outcomes Racial disparities

来  源:   DOI:10.1007/s11912-024-01578-7

Abstract:
OBJECTIVE: Analyze current evidence on racial/ethnic disparities in cardiovascular outcomes among cancer survivors, identifying factors and proposing measures to address health inequities.
RESULTS: Existing literature indicates that the Black population experiences worse cardiovascular outcomes following the diagnosis of both initial primary cancer and second primary cancer, with a notably higher prevalence of cardio-toxic events, particularly among breast cancer survivors. Contributing socioeconomic factors to these disparities include unfavorable social determinants of health, inadequate insurance coverage, and structural racism within the healthcare system. Additionally, proinflammatory epigenetic modification is hypothesized to be a contributing genetic variation factor. Addressing these disparities requires a multiperspective approach, encompassing efforts to address racial disparities and social determinants of health within the healthcare system, refine healthcare policies and access, and integrate historically stigmatized racial groups into clinical research. Racial and ethnic disparities persist in cardiovascular outcomes among cancer survivors, driven by multifactorial causes, predominantly associated with social determinants of health. Addressing these healthcare inequities is imperative, and timely efforts must be implemented to narrow the existing gap effectively.
摘要:
目的:分析癌症幸存者心血管疾病结局的种族/民族差异的当前证据,确定因素并提出解决健康不平等的措施。
结果:现有文献表明,在诊断为初始原发癌和第二原发癌后,黑人的心血管结局更差。心脏毒性事件的发生率明显较高,尤其是乳腺癌幸存者。造成这些差异的社会经济因素包括健康的不利社会决定因素,保险范围不足,以及医疗系统内的结构性种族主义。此外,促炎表观遗传修饰被认为是一个促成遗传变异的因素.解决这些差异需要多角度的方法,包括解决医疗系统内种族差异和健康的社会决定因素的努力,完善医疗保健政策和准入,并将历史上被污名化的种族群体纳入临床研究。种族和种族差异在癌症幸存者的心血管结局中仍然存在,由多因素原因驱动,主要与健康的社会决定因素有关。解决这些医疗保健不平等势在必行,必须及时努力,有效缩小现有差距。
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