Abstract：
Pancreatic cancer remains a significant health issue with limited treatment options. The tumor stroma, a complex environment made up of different cells and proteins, plays a crucial role in tumor growth and chemoresistance. Targeting tumor stroma, consisting of diverse non-tumor cells such as fibroblasts, extracellular matrix (ECM), immune cells, and also pre-vascular cells is encouraging for remodeling solid cancers, such as pancreatic cancer. Remodeling the stroma of pancreas tumors can be suggested as a strategy for reducing resistance to chemo/immunotherapy. Several studies have shown that phytochemicals from plants can affect the tumor environment and have anti-cancer properties. By targeting key pathways involved in stromal activation, phytochemicals may disrupt communication between the tumor and stroma and make tumor cells more sensitive to different treatments. Additionally, phytochemicals have immunomodulatory and anti-angiogenic properties, all of which contribute to their potential in treating pancreatic cancer. This review will provide a detailed look at how phytochemicals impact the tumor stroma and their effects on pancreatic tumor growth, spread, and response to treatment. It will also explore the potential of combining phytochemicals with other treatment options like chemotherapy, immunotherapy, and radiation.
摘要：
胰腺癌仍然是一个重要的健康问题，治疗选择有限。肿瘤间质,由不同的细胞和蛋白质组成的复杂环境，在肿瘤生长和化疗耐药中起着至关重要的作用。靶向肿瘤基质，由不同的非肿瘤细胞如成纤维细胞组成，细胞外基质（ECM），免疫细胞，血管前细胞也鼓励重塑实体癌，比如胰腺癌。重塑胰腺肿瘤的基质可以被建议作为降低对化学/免疫疗法的抗性的策略。一些研究表明，来自植物的植物化学物质可以影响肿瘤环境并具有抗癌特性。通过靶向参与基质激活的关键途径，植物化学物质可能会破坏肿瘤和间质之间的交流，使肿瘤细胞对不同的治疗方法更敏感。此外,植物化学物质具有免疫调节和抗血管生成特性，所有这些都有助于他们治疗胰腺癌的潜力。这篇综述将详细介绍植物化学物质如何影响肿瘤基质及其对胰腺肿瘤生长的影响。传播，以及对治疗的反应。它还将探索将植物化学物质与化疗等其他治疗方案相结合的潜力，免疫疗法，和辐射。
