Abstract：
OBJECTIVE: To evaluate glycemic variability (GV) using continuous glucose monitoring (CGM) in individuals with and without type 2 diabetes mellitus (T2DM) undergoing Roux-en-Y gastric bypass (RYGB).
METHODS: This prospective cohort study compared the CGM data of fourteen patients with T2DM (n = 7) and without T2DM (n = 7) undergoing RYGB. After 6 months, these patients were compared to a non-operative control group (n = 7) matched by BMI, sex, and age to the T2DM group.
RESULTS: Fourteen patients underwent RYGB, with a mean BMI of 46.9 ± 5.3 kg/m2 and an average age of 47.9 ± 8.9 years; 85% were female. After 6 months post-surgery, the total weight loss (TWL) was 27.1 ± 6.3%, with no significant differences between the groups. Patients without diabetes had lower mean interstitial glucose levels (81 vs. 94 and 98 mg/dl, p < 0.01) and lower glucose management indicator (GMI) (5.2 vs. 5.6 and 5.65%, p = 0.01) compared to the control and T2DM groups, respectively. The coefficient of variation (CV) significantly increased only in patients with diabetes (17% vs. 26.7%, p < 0.01). Both groups with (0% vs. 2%, p = 0.03) and without (3% vs. 22%, p = 0.03) T2DM experienced an increased time below range with low glucose (54-69 mg/dL). However, patients without T2DM had significantly less time in rage (70-180 mg/dL) (97% vs. 78%, p = 0.04).
CONCLUSIONS: Significant differences in CGM metrics among RYGB patients suggest an increase in glycemic variability after surgery, with a longer duration of hypoglycemia, especially in patients without T2DM.
METHODS: This prospective cohort study compared the CGM data of fourteen patients with T2DM (n = 7) and without T2DM (n = 7) undergoing RYGB. After 6 months, these patients were compared to a non-operative control group (n = 7) matched by BMI, sex, and age to the T2DM group.
RESULTS: Fourteen patients underwent RYGB, with a mean BMI of 46.9 ± 5.3 kg/m2 and an average age of 47.9 ± 8.9 years; 85% were female. After 6 months post-surgery, the total weight loss (TWL) was 27.1 ± 6.3%, with no significant differences between the groups. Patients without diabetes had lower mean interstitial glucose levels (81 vs. 94 and 98 mg/dl, p < 0.01) and lower glucose management indicator (GMI) (5.2 vs. 5.6 and 5.65%, p = 0.01) compared to the control and T2DM groups, respectively. The coefficient of variation (CV) significantly increased only in patients with diabetes (17% vs. 26.7%, p < 0.01). Both groups with (0% vs. 2%, p = 0.03) and without (3% vs. 22%, p = 0.03) T2DM experienced an increased time below range with low glucose (54-69 mg/dL). However, patients without T2DM had significantly less time in rage (70-180 mg/dL) (97% vs. 78%, p = 0.04).
CONCLUSIONS: Significant differences in CGM metrics among RYGB patients suggest an increase in glycemic variability after surgery, with a longer duration of hypoglycemia, especially in patients without T2DM.
摘要：
目的：使用连续血糖监测（CGM）评估接受Roux-en-Y胃旁路术（RYGB）的2型糖尿病（T2DM）患者的血糖变异性（GV）。
方法：这项前瞻性队列研究比较了14例接受RYGB的T2DM患者（n=7）和非T2DM患者（n=7）的CGM数据。六个月后,将这些患者与BMI相匹配的非手术对照组（n=7）进行比较，性别,和年龄为T2DM组。
结果：14例患者接受了RYGB，平均BMI为46.9±5.3kg/m2，平均年龄为47.9±8.9岁；85%为女性。手术后6个月，总重量损失（TWL）为27.1±6.3％，组间无显著差异。无糖尿病患者的平均间质葡萄糖水平较低（81vs.94和98mg/dl，p<0.01）和较低的血糖管理指标（GMI）（5.2vs.5.6%和5.65%，p=0.01）与对照组和T2DM组相比，分别。仅糖尿病患者的变异系数（CV）显着增加（17％vs.26.7%,p<0.01)。两组都有(0%vs.2%,p=0.03)和无(3%与22%,p=0.03)T2DM在低葡萄糖(54-69mg/dL)下经历低于范围的时间增加。然而,无T2DM患者的发病时间明显减少（70-180mg/dL）（97％vs.78%,p=0.04)。
结论：RYGB患者中CGM指标的显著差异表明手术后血糖变异性增加，低血糖持续时间较长，特别是在没有T2DM的患者中。
方法：这项前瞻性队列研究比较了14例接受RYGB的T2DM患者（n=7）和非T2DM患者（n=7）的CGM数据。六个月后,将这些患者与BMI相匹配的非手术对照组（n=7）进行比较，性别,和年龄为T2DM组。
结果：14例患者接受了RYGB，平均BMI为46.9±5.3kg/m2，平均年龄为47.9±8.9岁；85%为女性。手术后6个月，总重量损失（TWL）为27.1±6.3％，组间无显著差异。无糖尿病患者的平均间质葡萄糖水平较低（81vs.94和98mg/dl，p<0.01）和较低的血糖管理指标（GMI）（5.2vs.5.6%和5.65%，p=0.01）与对照组和T2DM组相比，分别。仅糖尿病患者的变异系数（CV）显着增加（17％vs.26.7%,p<0.01)。两组都有(0%vs.2%,p=0.03)和无(3%与22%,p=0.03)T2DM在低葡萄糖(54-69mg/dL)下经历低于范围的时间增加。然而,无T2DM患者的发病时间明显减少（70-180mg/dL）（97％vs.78%,p=0.04)。
结论：RYGB患者中CGM指标的显著差异表明手术后血糖变异性增加，低血糖持续时间较长，特别是在没有T2DM的患者中。
