关键词: central adrenal insufficiency central hypothyroidism hypogonadism hypophysitis hypopituitarism immune checkpoint inhibitors

Mesh : Humans Immune Checkpoint Inhibitors / adverse effects Autoimmune Hypophysitis / chemically induced Pituitary Diseases / chemically induced Immunotherapy / adverse effects Neoplasms / drug therapy

来  源:   DOI:10.1210/endocr/bqae084

Abstract:
Immune checkpoint inhibitors have revolutionized cancer therapy but are associated with a risk of endocrine immune-related adverse events, including pituitary complications. Autoimmune hypophysitis, traditionally a rare diagnosis, has become a more frequently encountered clinical entity with the emergence of antitumor immunotherapy. This mini-review aims to consolidate current knowledge, encompassing the epidemiology, pathophysiology, clinical presentation, diagnosis, and management of pituitary complications of immune checkpoint inhibitor use.
摘要:
免疫检查点抑制剂(ICIs)彻底改变了癌症治疗,但与内分泌免疫相关不良事件(irAE)的风险有关。包括垂体并发症.自身免疫性垂体炎,传统上是一种罕见的诊断,随着抗肿瘤免疫疗法的出现,已成为更频繁遇到的临床实体。这个小型审查旨在巩固当前的知识,包括流行病学,病理生理学,临床表现,诊断,ICI使用的垂体并发症的处理。
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