Abstract：
The improvement in congenital heart disease (CHD) treatment and management has increased the life expectancy in infants. However, the long-term efficacy is difficult to assess and thus, computational modelling has been applied for evaluating this. Here, we provide an overview of the applications of computational modelling in CHD based on three categories; CHD involving large blood vessels only, heart chambers only, and CHD that occurs at multiple heart structures. We highlight the advancement of computational simulation of CHD that uses multiscale and multiphysics modelling to ensure a complete representation of the heart and circulation. We provide a brief future direction of computational modelling of CHD such as to include growth and remodelling, detailed conduction system, and occurrence of myocardial infarction. We also proposed validation technique using advanced three-dimensional (3D) printing and particle image velocimetry (PIV) technologies to improve the model accuracy.
摘要：
先天性心脏病（CHD）治疗和管理的改善增加了婴儿的预期寿命。然而,长期疗效难以评估，因此，计算模型已被用于评估这一点。这里,我们基于三个类别概述了计算建模在CHD中的应用；仅涉及大血管的CHD，仅心室，和发生在多个心脏结构的冠心病。我们强调使用多尺度和多物理场建模的CHD计算模拟的进步，以确保心脏和循环的完整表示。我们提供了CHD计算建模的简要未来方向，例如包括增长和重建，详细的传导系统，和心肌梗塞的发生。我们还提出了使用先进的三维（3D）打印和粒子图像测速（PIV）技术来提高模型精度的验证技术。
