OBJECTIVE: This meta-analysis and systematic review aimed to explore the CXI\'s prognostic value in patients with cancer.
METHODS: The PubMed, Embase, MEDLINE, and Cochrane Library databases were searched for relevant studies to determine the association between CXI findings and prognosis.
METHODS: The outcomes were overall survival (OS), progression-, disease-, and recurrence-free survival (PFS/DFS/RFS) rates, and the rate of complete response.
METHODS: The QUality In Prognostic Studies (QUIPS) tool was used to evaluate the quality of the included trials. This meta-analysis comprised 14 studies involving 2777 patients. A low CXI was associated with decreased OS (hazard ratio [HR] 2.34, 95% confidence interval [CI] 2.01-2.72; P < .001), PFS/DFS/RFS (HR 1.93, 95% CI 1.68-2.22; P < .001), and complete response (odds ratio [OR] 0.49, 95% CI 0.36-0.66; P < .001). Patients with a low CXI had a lower body mass index (mean difference [MD] -0.75, 95% CI -1.00 to 0.50; P < .001), skeletal muscle index (standardized MD -0.80, 95% CI -0.98 to -0.61; P < .001), and serum albumin level (MD -0.23, 95% CI -0.26 to -0.20; P < .001); and a higher neutrophil-lymphocyte ratio (MD 1.88, 95% CI 1.29-2.47; P < .001) and more advanced disease stages (OR 0.80, 95% CI 0.71-0.91; P = .001).
CONCLUSIONS: A low CXI was found to be associated with poor survival in patients with cancer. While the CXI is a promising marker for predicting cancer cachexia, further studies are required to verify its usefulness.
目的:本荟萃分析和系统评价旨在探讨CXI在癌症患者中的预后价值。
方法:PubMed,Embase,MEDLINE,我们在CochraneLibrary数据库中搜索相关研究,以确定CXI结果与预后之间的关联.
方法:结果是总生存期(OS),进度-,疾病-,和无复发生存率(PFS/DFS/RFS),以及完全反应率。
方法:使用预后研究质量(QUIPS)工具评估纳入试验的质量。这项荟萃分析包括14项研究,涉及2777名患者。低CXI与OS降低相关(风险比[HR]2.34,95%置信区间[CI]2.01-2.72;P<.001),PFS/DFS/RFS(HR1.93,95%CI1.68-2.22;P<.001),和完全缓解(比值比[OR]0.49,95%CI0.36-0.66;P<.001)。低CXI患者的体重指数较低(平均差异[MD]-0.75,95%CI-1.00至0.50;P<.001),骨骼肌指数(标准化MD-0.80,95%CI-0.98至-0.61;P<.001),和血清白蛋白水平(MD-0.23,95%CI-0.26至-0.20;P<.001);中性粒细胞-淋巴细胞比率较高(MD1.88,95%CI1.29-2.47;P<.001)和更晚期的疾病阶段(OR0.80,95%CI0.71-0.91;P=.001)。
结论:发现低CXI与癌症患者的低生存率相关。虽然CXI是预测癌症恶病质的有希望的标志物,需要进一步的研究来验证其有效性。