Abstract：
The central nervous system (CNS) plays a role in regulating heart rate and myocardial contractility through sympathetic and parasympathetic nerves, and the heart can impact the functional equilibrium of the CNS through feedback signals. Although heart and brain diseases often coexist and mutually influence each other, the potential links between heart and brain diseases remain unclear due to a lack of reliable models of these relationships. Induced pluripotent stem cells (iPSCs), which can differentiate into multiple functional cell types, stem cell biology and regenerative medicine may offer tools to clarify the mechanisms of these relationships and facilitate screening of effective therapeutic agents. Because calcium ions play essential roles in regulating both the cardiovascular and nervous systems, this review addresses how recent iPSC disease models reveal how dysregulation of intracellular calcium might be a common pathological factor underlying the relationships between heart and brain diseases.
摘要：
中枢神经系统（CNS）通过交感神经和副交感神经在调节心率和心肌收缩力方面发挥作用，心脏可以通过反馈信号影响中枢神经系统的功能平衡。虽然心脑疾病往往共存，相互影响，心脏疾病和脑部疾病之间的潜在联系仍不清楚，因为缺乏可靠的模型。诱导多能干细胞（iPSCs），可以分化为多种功能细胞类型，干细胞生物学和再生医学可能提供工具来阐明这些关系的机制，并促进有效治疗药物的筛选。因为钙离子在调节心血管和神经系统中起着至关重要的作用，这篇综述探讨了最近的iPSC疾病模型如何揭示细胞内钙的失调可能是心脑疾病之间关系的共同病理因素.
