Abstract：
Cigarette smoking exacerbates respiratory diseases, while plant-derived polyphenols offer antioxidant and anti-inflammatory benefits. This study explores the effects of Rhoifolin (ROF), a polyphenol from Jordanian Teucrium polium, on lung health in rats exposed to tobacco smoke. Male rats were divided into two groups: one exposed to cigarette smoke (CS), and the other to ROF treatment alongside smoke exposure (ROF/CS). ROF was administered orally for 21 days before smoke exposure. Results showed smoke-induced lung inflammation and oxidative stress, mitigated by ROF treatment. Histological examination revealed smoke-related morphological changes in lung tissue. ROF treatment reduced oxidative stress and inflammation, as evidenced by decreased proinflammatory cytokines. In silico docking demonstrated ROF\'s potential as an inhibitor. This study suggests the therapeutic potential of ROF and similar polyphenols in mitigating the harmful effects of cigarette smoke on lung health.
摘要：
吸烟会加剧呼吸道疾病,而植物来源的多酚提供抗氧化和抗炎的好处。本研究探讨了罗素（ROF）的作用，来自约旦的一种多酚，暴露于烟草烟雾的大鼠的肺部健康。雄性大鼠分为两组：一组暴露于香烟烟雾（CS），另一种是在烟雾暴露(ROF/CS)的同时进行ROF处理。在烟雾暴露前口服ROF21天。结果显示烟雾引起的肺部炎症和氧化应激，通过ROF治疗缓解。组织学检查显示肺组织中烟雾相关的形态学变化。ROF治疗减少氧化应激和炎症，如减少的促炎细胞因子所证明。硅基对接证明了ROF作为抑制剂的潜力。这项研究表明，ROF和类似的多酚在减轻香烟烟雾对肺部健康的有害影响方面具有治疗潜力。
