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Abstract：
BACKGROUND: Sellar masses are common intracranial neoplasms. Their clinical manifestations vary widely and include headache. We aimed to determine whether the prevalence and characteristics of headache in patients with sellar tumours differ from the general population and to investigate the effect of tumour resection on this complaint.
METHODS: We performed a prospective, controlled study in a single tertiary centre and included 57 patients that underwent transsphenoidal resection for a sellar mass (53% females, mean age 53.5 ± 16.4) and 29 of their partners (controls; 45% females, mean age 54.8 ± 14.9). Outcome measures were prevalence, characteristics and impact of headache 1 month preoperatively and at neurosurgical follow-up 3 months postoperatively.
RESULTS: Preoperatively, the prevalence of regular headache (≥1 time per month) was higher in patients than in controls (54% vs. 17%, p < 0.001), and patients scored higher on headache impact questionnaires (all p ≤ 0.01). At postoperative follow-up, headache prevalence decreased in both groups, but the decrease in regular headache frequency and impact was larger in patients than in controls, and no between-group differences remained.
CONCLUSIONS: More than half of patients with sellar tumours suffer from at least once-monthly headaches, and both regular headache occurrence and impact are higher compared with controls. The more pronounced decrease in headache complaints in patients versus controls at postoperative follow-up suggests an additional effect of tumour resection next to the factor time.
METHODS: We performed a prospective, controlled study in a single tertiary centre and included 57 patients that underwent transsphenoidal resection for a sellar mass (53% females, mean age 53.5 ± 16.4) and 29 of their partners (controls; 45% females, mean age 54.8 ± 14.9). Outcome measures were prevalence, characteristics and impact of headache 1 month preoperatively and at neurosurgical follow-up 3 months postoperatively.
RESULTS: Preoperatively, the prevalence of regular headache (≥1 time per month) was higher in patients than in controls (54% vs. 17%, p < 0.001), and patients scored higher on headache impact questionnaires (all p ≤ 0.01). At postoperative follow-up, headache prevalence decreased in both groups, but the decrease in regular headache frequency and impact was larger in patients than in controls, and no between-group differences remained.
CONCLUSIONS: More than half of patients with sellar tumours suffer from at least once-monthly headaches, and both regular headache occurrence and impact are higher compared with controls. The more pronounced decrease in headache complaints in patients versus controls at postoperative follow-up suggests an additional effect of tumour resection next to the factor time.
摘要：
背景：鞍区肿块是常见的颅内肿瘤。其临床表现差异很大，包括头痛。我们旨在确定鞍区肿瘤患者头痛的患病率和特征是否与普通人群不同，并研究肿瘤切除对该疾病的影响。
方法：我们进行了前瞻性，在单个三级中心进行的对照研究，包括57例因鞍区肿块而接受经蝶窦切除术的患者（53％为女性，平均年龄53.5±16.4)和29岁的伴侣(对照组；45%的女性，平均年龄54.8±14.9）。结果指标是患病率，术前1个月和术后3个月神经外科随访时头痛的特点和影响。
结果：术前，患者定期头痛（每月≥1次）的患病率高于对照组（54％vs.17%,p<0.001)，患者在头痛影响问卷中得分较高（均p≤0.01）。在术后随访时，两组的头痛患病率均下降，但是患者的常规头痛频率和影响的减少比对照组更大，组间没有差异。
结论：超过一半的鞍区肿瘤患者每月至少有一次头痛，与对照组相比，经常性头痛的发生率和影响均较高。术后随访时，与对照组相比，患者的头痛投诉更明显地减少，这表明在因素时间之后，肿瘤切除会产生额外的影响。
方法：我们进行了前瞻性，在单个三级中心进行的对照研究，包括57例因鞍区肿块而接受经蝶窦切除术的患者（53％为女性，平均年龄53.5±16.4)和29岁的伴侣(对照组；45%的女性，平均年龄54.8±14.9）。结果指标是患病率，术前1个月和术后3个月神经外科随访时头痛的特点和影响。
结果：术前，患者定期头痛（每月≥1次）的患病率高于对照组（54％vs.17%,p<0.001)，患者在头痛影响问卷中得分较高（均p≤0.01）。在术后随访时，两组的头痛患病率均下降，但是患者的常规头痛频率和影响的减少比对照组更大，组间没有差异。
结论：超过一半的鞍区肿瘤患者每月至少有一次头痛，与对照组相比，经常性头痛的发生率和影响均较高。术后随访时，与对照组相比，患者的头痛投诉更明显地减少，这表明在因素时间之后，肿瘤切除会产生额外的影响。
