METHODS: We performed a prospective, controlled study in a single tertiary centre and included 57 patients that underwent transsphenoidal resection for a sellar mass (53% females, mean age 53.5 ± 16.4) and 29 of their partners (controls; 45% females, mean age 54.8 ± 14.9). Outcome measures were prevalence, characteristics and impact of headache 1 month preoperatively and at neurosurgical follow-up 3 months postoperatively.
RESULTS: Preoperatively, the prevalence of regular headache (≥1 time per month) was higher in patients than in controls (54% vs. 17%, p < 0.001), and patients scored higher on headache impact questionnaires (all p ≤ 0.01). At postoperative follow-up, headache prevalence decreased in both groups, but the decrease in regular headache frequency and impact was larger in patients than in controls, and no between-group differences remained.
CONCLUSIONS: More than half of patients with sellar tumours suffer from at least once-monthly headaches, and both regular headache occurrence and impact are higher compared with controls. The more pronounced decrease in headache complaints in patients versus controls at postoperative follow-up suggests an additional effect of tumour resection next to the factor time.
方法:我们进行了前瞻性,在单个三级中心进行的对照研究,包括57例因鞍区肿块而接受经蝶窦切除术的患者(53%为女性,平均年龄53.5±16.4)和29岁的伴侣(对照组;45%的女性,平均年龄54.8±14.9)。结果指标是患病率,术前1个月和术后3个月神经外科随访时头痛的特点和影响。
结果:术前,患者定期头痛(每月≥1次)的患病率高于对照组(54%vs.17%,p<0.001),患者在头痛影响问卷中得分较高(均p≤0.01)。在术后随访时,两组的头痛患病率均下降,但是患者的常规头痛频率和影响的减少比对照组更大,组间没有差异。
结论:超过一半的鞍区肿瘤患者每月至少有一次头痛,与对照组相比,经常性头痛的发生率和影响均较高。术后随访时,与对照组相比,患者的头痛投诉更明显地减少,这表明在因素时间之后,肿瘤切除会产生额外的影响。