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Abstract：
BACKGROUND: Papilloma DNA viruses are one of the viruses that cause skin lesions in ruminants.
OBJECTIVE: The clinical, histopathological and molecular characteristics of cutaneous papilloma in ruminants in Iran are to be investigated in this study.
METHODS: Samples were collected from 19 small ruminants (5 sheep and 14 goats) with various papillomatosis lesions. The samples taken were studied with histopathological and molecular techniques.
RESULTS: In clinical terms, the lesions appeared in different sizes, ranging from 0.5 to 11 cm, and the cauliflower exophytic masses appeared in other parts of the animal\'s body. In the limbs, most papilloma lesions have been seen (42.1%). In histopathological examination, perinuclear vacuolation epidermal granule layer with various degrees of hypergranulosis, hyperkeratosis, acanthosis, orthokeratosis and parakeratosis were seen. Moreover, all the suspected samples were positive for papillomavirus using the polymerase chain reaction technique.
CONCLUSIONS: Although the prevalence of papillomaviruses in Iranian sheep and goats is low, it seems necessary to distinguish them from other viral skin diseases, such as cutaneous contagious ecthyma, using molecular techniques and histopathology.
OBJECTIVE: The clinical, histopathological and molecular characteristics of cutaneous papilloma in ruminants in Iran are to be investigated in this study.
METHODS: Samples were collected from 19 small ruminants (5 sheep and 14 goats) with various papillomatosis lesions. The samples taken were studied with histopathological and molecular techniques.
RESULTS: In clinical terms, the lesions appeared in different sizes, ranging from 0.5 to 11 cm, and the cauliflower exophytic masses appeared in other parts of the animal\'s body. In the limbs, most papilloma lesions have been seen (42.1%). In histopathological examination, perinuclear vacuolation epidermal granule layer with various degrees of hypergranulosis, hyperkeratosis, acanthosis, orthokeratosis and parakeratosis were seen. Moreover, all the suspected samples were positive for papillomavirus using the polymerase chain reaction technique.
CONCLUSIONS: Although the prevalence of papillomaviruses in Iranian sheep and goats is low, it seems necessary to distinguish them from other viral skin diseases, such as cutaneous contagious ecthyma, using molecular techniques and histopathology.
摘要：
背景：乳头状瘤DNA病毒是引起反刍动物皮肤损伤的病毒之一。
目的：临床，本研究将研究伊朗反刍动物皮肤乳头状瘤的组织病理学和分子特征。
方法：从具有各种乳头状瘤病病变的19只小反刍动物（5只绵羊和14只山羊）中收集样本。用组织病理学和分子技术研究了所采集的样品。
结果：在临床方面，病变大小不同,范围从0.5到11厘米，花椰菜的外生肿块出现在动物身体的其他部位。在四肢，已见到大多数乳头状瘤病变（42.1％）。在组织病理学检查中，核周空泡化表皮颗粒层具有不同程度的高颗粒病，角化过度,棘皮病,可见角膜塑形和角化不全。此外，使用聚合酶链反应技术,所有疑似样本的乳头状瘤病毒均呈阳性.
结论：尽管伊朗绵羊和山羊中乳头状瘤病毒的流行率很低，似乎有必要将它们与其他病毒性皮肤病区分开来，如皮肤传染性的湿疹，使用分子技术和组织病理学。
目的：临床，本研究将研究伊朗反刍动物皮肤乳头状瘤的组织病理学和分子特征。
方法：从具有各种乳头状瘤病病变的19只小反刍动物（5只绵羊和14只山羊）中收集样本。用组织病理学和分子技术研究了所采集的样品。
结果：在临床方面，病变大小不同,范围从0.5到11厘米，花椰菜的外生肿块出现在动物身体的其他部位。在四肢，已见到大多数乳头状瘤病变（42.1％）。在组织病理学检查中，核周空泡化表皮颗粒层具有不同程度的高颗粒病，角化过度,棘皮病,可见角膜塑形和角化不全。此外，使用聚合酶链反应技术,所有疑似样本的乳头状瘤病毒均呈阳性.
结论：尽管伊朗绵羊和山羊中乳头状瘤病毒的流行率很低，似乎有必要将它们与其他病毒性皮肤病区分开来，如皮肤传染性的湿疹，使用分子技术和组织病理学。
