Abstract：
OBJECTIVE: This study aimed to evaluate the intensity of the subacute local biological effects after implantation and osseoconductive potential of novel hydroxyapatite-based bone substitute coated with poly (lactide-co-glycolide), named ALBO-OS, in comparison to Bio-Oss®.
METHODS: Fifteen male Wistar rats, randomly assigned into groups: 10, 20, and 30 days (n꞊5), were subcutaneously implanted with ALBO-OS and Bio-Oss®. Furthermore, artificially made bone defects on both rat\'s tibias were implanted with experimental materials. Unimplanted defects represented negative control. After the animals\' euthanizing, tissue samples were prepared and analyzed histologically and histomorphometrically.
RESULTS: Normal healing of the epithelial tissue was observed, with no signs of infection or necrosis. Minimal vascular congestion was noted immediately around the graft, with no signs of tissue oedema, with a minimal capsule thickness. The applied material did not cause an inflammatory response (IR) of significant intensity, and 20 days after implantation, the IR was mainly assessed as minimal. The tibial specimen showed that ALBO-OS has good osseoconductive potential, similar to Bio-Oss®, as well as low levels of acute and subacute inflammation.
CONCLUSIONS: The tested material exhibits satisfying biocompatibility, similar to Bio-Oss®.
METHODS: Fifteen male Wistar rats, randomly assigned into groups: 10, 20, and 30 days (n꞊5), were subcutaneously implanted with ALBO-OS and Bio-Oss®. Furthermore, artificially made bone defects on both rat\'s tibias were implanted with experimental materials. Unimplanted defects represented negative control. After the animals\' euthanizing, tissue samples were prepared and analyzed histologically and histomorphometrically.
RESULTS: Normal healing of the epithelial tissue was observed, with no signs of infection or necrosis. Minimal vascular congestion was noted immediately around the graft, with no signs of tissue oedema, with a minimal capsule thickness. The applied material did not cause an inflammatory response (IR) of significant intensity, and 20 days after implantation, the IR was mainly assessed as minimal. The tibial specimen showed that ALBO-OS has good osseoconductive potential, similar to Bio-Oss®, as well as low levels of acute and subacute inflammation.
CONCLUSIONS: The tested material exhibits satisfying biocompatibility, similar to Bio-Oss®.
摘要：
目的：本研究旨在评估涂覆有聚（丙交酯-共-乙交酯）的新型羟基磷灰石基骨替代物植入后亚急性局部生物学效应的强度和骨传导潜力，名为ALBO-OS,与Bio-Oss®相比。
方法：15只雄性Wistar大鼠,随机分组：10、20和30天（n5），皮下植入ALBO-OS和Bio-Oss®。此外，人工制作的骨缺损在两只大鼠的胫骨上植入实验材料。未植入缺陷代表阴性对照。动物安乐死后，制备组织样本，并进行组织学和组织形态分析。
结果：上皮组织正常愈合，没有感染或坏死的迹象。移植物周围立即观察到最小的血管充血，没有组织水肿的迹象，具有最小的胶囊厚度。施加的材料没有引起显著强度的炎症反应(IR),植入后20天，IR主要评估为最小。胫骨标本显示ALBO-OS具有良好的骨传导电位,类似于Bio-Oss®，以及低水平的急性和亚急性炎症。
结论：所测试的材料表现出令人满意的生物相容性，类似于Bio-Oss®。
方法：15只雄性Wistar大鼠,随机分组：10、20和30天（n
结果：上皮组织正常愈合，没有感染或坏死的迹象。移植物周围立即观察到最小的血管充血，没有组织水肿的迹象，具有最小的胶囊厚度。施加的材料没有引起显著强度的炎症反应(IR),植入后20天，IR主要评估为最小。胫骨标本显示ALBO-OS具有良好的骨传导电位,类似于Bio-Oss®，以及低水平的急性和亚急性炎症。
结论：所测试的材料表现出令人满意的生物相容性，类似于Bio-Oss®。
