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Abstract：
Significance: Despite the widespread use of photodynamic therapy in clinical practice, there is a lack of personalized methods for assessing the sufficiency of photodynamic exposure on tumors, depending on tissue parameters that change during light irradiation. This can lead to different treatment results. Aim: The objective of this article was to conduct a comprehensive review of devices and methods employed for the implicit dosimetric monitoring of personalized photodynamic therapy for tumors. Methods: The review included 88 peer-reviewed research articles published between January 2010 and April 2024 that employed implicit monitoring methods, such as fluorescence imaging and diffuse reflectance spectroscopy. Additionally, it encompassed computer modeling methods that are most often and successfully used in preclinical and clinical practice to predict treatment outcomes. The Internet search engine Google Scholar and the Scopus database were used to search the literature for relevant articles. Results: The review analyzed and compared the results of 88 peer-reviewed research articles presenting various methods of implicit dosimetry during photodynamic therapy. The most prominent wavelengths for PDT are in the visible and near-infrared spectral range such as 405, 630, 660, and 690 nm. Conclusions: The problem of developing an accurate, reliable, and easily implemented dosimetry method for photodynamic therapy remains a current problem, since determining the effective light dose for a specific tumor is a decisive factor in achieving a positive treatment outcome.
摘要：
意义：尽管光动力疗法在临床实践中广泛使用，缺乏个性化的方法来评估光动力暴露对肿瘤的充分性，取决于在光照过程中改变的组织参数。这可能导致不同的处理结果。目的：本文的目的是对用于肿瘤个性化光动力疗法的隐式剂量监测的设备和方法进行全面审查。方法：该综述包括2010年1月至2024年4月发表的88篇同行评审的研究文章，这些文章采用了内隐监测方法，如荧光成像和漫反射光谱。此外,它涵盖了在临床前和临床实践中最常用且最成功地用于预测治疗结果的计算机建模方法.互联网搜索引擎GoogleScholar和Scopus数据库用于搜索相关文章的文献。结果：该综述分析并比较了88篇同行评审的研究文章的结果，这些文章介绍了光动力疗法期间的各种隐式剂量测定方法。PDT最突出的波长是在可见和近红外光谱范围内,例如405、630、660和690nm。结论：开发准确的问题，可靠,光动力疗法的易于实施的剂量测定方法仍然是当前的问题，因为确定特定肿瘤的有效光剂量是获得积极治疗结果的决定性因素。
