PDF(Pubmed)
Abstract：
Breast cancer is one of the most frequently detected malignancies worldwide. It is responsible for more than 15% of all death cases caused by cancer in women. Breast cancer is a heterogeneous disease representing various histological types, molecular characteristics, and clinical profiles. However, all breast cancers are organized in a hierarchy of heterogeneous cell populations, with a small proportion of cancer stem cells (breast cancer stem cells (BCSCs)) playing a putative role in cancer progression, and they are responsible for therapeutic failure. In different molecular subtypes of breast cancer, they present different characteristics, with specific marker profiles, prognoses, and treatments. Recent efforts have focused on tackling the Wnt, Notch, Hedgehog, PI3K/Akt/mTOR, and HER2 signaling pathways. Developing diagnostics and therapeutic strategies enables more efficient elimination of the tumor mass together with the stem cell population. Thus, the knowledge about appropriate therapeutic methods targeting both \"normal\" breast cancer cells and breast cancer stem cell subpopulations is crucial for success in cancer elimination.
摘要：
乳腺癌是全世界最常见的恶性肿瘤之一。它占女性癌症引起的所有死亡病例的15％以上。乳腺癌是代表各种组织学类型的异质性疾病，分子特征，和临床资料。然而,所有的乳腺癌都组织在异质细胞群的层次结构中，一小部分癌症干细胞（乳腺癌干细胞（BCSC））在癌症进展中起着推定的作用，他们负责治疗失败。在乳腺癌的不同分子亚型中，它们呈现出不同的特点，具有特定的标记配置文件，预后,和治疗。最近的努力集中在解决Wnt，缺口,刺猬,PI3K/Akt/mTOR,和HER2信号通路。开发诊断和治疗策略能够更有效地消除肿瘤块和干细胞群。因此，关于针对“正常”乳腺癌细胞和乳腺癌干细胞亚群的适当治疗方法的知识对于成功消除癌症至关重要。
