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Abstract：
Appendiceal tumors are uncommon and, at times, discovered incidentally during histological examination. The histopathological classification of the disease is complex and has generated some controversy. The analysis of circulating tumor cells can be used for the early detection of metastatic potential. The aim of the present study was to examine the prognostic value of circulating tumor cells in patients with appendiceal tumors and peritoneal metastases. To our knowledge, this is the first study to examine CTCs in appendiceal tumors. We performed a prospective cohort study of consecutive patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy between 2015 and 2019 at a HIPEC referral center. In total, 31 patients were included in the analysis, and circulating tumor cells were detected in 15 patients (48%). CTC positivity was not associated with overall or recurrence-free survival, nor was it correlated with PCI score or histopathological grading. Surprisingly, however, CTCs were found in almost half the patients. The presence or quantities of these cells did not, on their own, predict systemic metastatic potential during the observed time, and they did not appear to significantly correlate with the oncological outcomes recorded.
摘要：
阑尾肿瘤并不常见，有时,在组织学检查中偶然发现。该疾病的组织病理学分类很复杂，并引起了一些争议。循环肿瘤细胞的分析可用于转移潜能的早期检测。本研究的目的是检查阑尾肿瘤和腹膜转移患者循环肿瘤细胞的预后价值。据我们所知,这是第一项检查阑尾肿瘤CTC的研究.我们对2015年至2019年在HIPEC转诊中心接受细胞减灭术和腹腔热化疗的连续患者进行了一项前瞻性队列研究。总的来说,31例患者被纳入分析，15例(48%)患者中检测到循环肿瘤细胞。CTC阳性与总生存期或无复发生存期无关，也不与PCI评分或组织病理学分级相关.令人惊讶的是,然而,在几乎一半的患者中发现了CTC。这些细胞的存在或数量没有，靠自己,预测观察时间内的全身转移潜力，它们似乎与记录的肿瘤结局无显著相关性.
