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Abstract：
Rising cancer survival rates have led to an increased risk of multiple primary cancers (MPCs). Data on MPCs in South Korea are limited. This study aimed to address incidence and clinical characteristics of MPCs in a single cancer center in Korea during a 20-year period. We retrospectively analyzed 96,174 cancer patients at the Korea Cancer Center Hospital between 2003 and 2022, identifying 2167 patients with metachronous MPCs based on Surveillance, Epidemiology, and End Results SEER criteria. We categorized patients by cancer type (15 major solid cancer groups and 3 major hematologic cancer groups), including pathological diagnosis, assessed latency periods, and relative risks (RRs) for developing MPCs. The overall MPC incidence was 2.3%. Breast cancer (15.7%) was the most common primary cancer, and lung cancer (15.2%) was the most frequent second primary cancer. The median latency period for second primary cancers was 4.1 years. Decreasing latency periods for third and fourth primary cancers were observed (2.1 years and 1.6 years, respectively). Most cancers maintained their dominant pathological type despite notable changes in the prevalence of specific pathologies for certain types of second primaries. Lymphoma showed the highest RR (2.1) for developing MPCs. Significant associations were found between specific primary and subsequent cancers, including breast-ovary, thyroid-breast, stomach-pancreas, colorectal-head and neck, lung-prostate, and lymphoma-myeloid neoplasms. These findings contribute to a better understanding of MPC occurrence. They can inform future research on their etiology and development of improved management strategies.
摘要：
癌症存活率的上升导致多原发癌(MPC)的风险增加。韩国的MPC数据有限。这项研究旨在解决20年期间韩国单一癌症中心MPC的发病率和临床特征。我们回顾性分析了2003年至2022年间在韩国癌症中心医院的96,174名癌症患者，根据监测确定了2167名患有异时MPC的患者。流行病学,和最终结果SEER标准。我们按癌症类型对患者进行分类（15个主要实体癌组和3个主要血液癌症组），包括病理诊断,评估的潜伏期，和开发MPC的相对风险(RR)。总体MPC发生率为2.3%。乳腺癌（15.7%）是最常见的原发癌，肺癌（15.2%）是最常见的第二原发癌。第二原发癌的中位潜伏期为4.1年。观察到第三和第四原发癌的潜伏期减少（2.1年和1.6年，分别)。尽管某些类型的第二原发特定病理的患病率发生了显着变化，但大多数癌症仍保持其主要病理类型。淋巴瘤在发展中的MPC中显示出最高的RR（2.1）。在特定的原发性和后续癌症之间发现了显着的关联，包括乳腺-卵巢,甲状腺-乳腺，胃胰腺,结直肠头颈部,肺-前列腺,和淋巴瘤-髓样肿瘤。这些发现有助于更好地理解MPC的发生。他们可以为未来的病因研究和改进的管理策略的发展提供信息。
