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Abstract：
With one third of patients with locally advanced cervical cancer (LACC) expected to develop cancer recurrence in the first two years after therapy, accurate assessment of the response and timely detection of cancer recurrence after concurrent chemo- and radiotherapy (CCRT) treatment is of great importance. Although there is neither definite consensus about the preferred imaging modality, nor the time interval until the first diagnostic examination after CCRT, the National Comprehensive Cancer Network (NCCN) recommends the use of MRI and 18F-FDG PET/CT as a post-treatment LACC response-assessment imaging tools. In this study, we tried to appraise the early therapy response in LACC patients by both 18F-FDG PET/CT and MRI in regard to the follow-up imaging results and their mutual interrelationship, and to ascertain if the post-treatment 18F-FDG PET/CT and MRI results were related to the progression-free and overall survival rate in women with LACC after CCRT. We also aimed to estimate the early and follow-up diagnostic imaging impact on further therapy management. Based on our results, we concluded that 18F-FDG PET/CT did surpass MRI in the early assessment of therapeutic response in LACC patients after CCRT. Both modalities provided information that may serve as predictive biomarkers of outcome and LACC patients\' survival.
摘要：
1/3的局部晚期宫颈癌（LACC）患者预计在治疗后的头两年内发生癌症复发，在同步化疗和放疗（CCRT）治疗后，准确评估反应并及时发现癌症复发非常重要。尽管对首选的成像模式没有明确的共识，也没有时间间隔，直到CCRT后的第一次诊断检查，国家综合癌症网络(NCCN)推荐使用MRI和18F-FDGPET/CT作为治疗后LACC反应评估成像工具.在这项研究中,我们试图通过18F-FDGPET/CT和MRI评估LACC患者的早期治疗反应，以评估随访影像学结果及其相互关系，并确定治疗后18F-FDGPET/CT和MRI结果是否与CCRT后LACC女性的无进展生存率和总体生存率相关。我们还旨在评估早期和后续诊断成像对进一步治疗管理的影响。根据我们的结果,我们的结论是18F-FDGPET/CT在CCRT后LACC患者治疗反应的早期评估中确实超过了MRI.两种模式都提供了可以作为预后和LACC患者生存的预测生物标志物的信息。
