PDF(Pubmed)
Abstract：
Glaucoma remains the primary cause of long-term blindness. While diabetes mellitus (DM) and hypertension (HTN) are known to influence glaucoma, other factors such as age and sex may be involved. In this retrospective study, we aimed to investigate the associations between age, sex, DM, HTN, and glaucoma risk. We employed optical coherence tomography (OCT) conducted using a 200 × 200-pixel optic cube (Cirrus HD OCT 6000, version 10.0; Carl Zeiss Meditec, Dublin, CA, USA). Effects obscured by low-test signals were disregarded. Data were amassed from 1337 patients. Among them, 218 and 402 patients had DM and HTN, respectively, with 133 (10%) exhibiting both. A sex-based comparison revealed slightly greater retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness in females. Patients without DM and HTN were predominantly in their 50 s and 60 s, whereas DM and HTN were most prevalent in those in their 60 s and 70 s. Both RNFL and GCIPL thicknesses decreased with advancing age in most patients. The study revealed that older individuals were more prone to glaucoma than younger individuals, with a higher incidence among patients with DM and HTN and reduced RNFL and GCIPL thicknesses. Furthermore, early detection before advancing age could furnish valuable preventive insights.
摘要：
青光眼仍然是长期失明的主要原因。虽然已知糖尿病（DM）和高血压（HTN）会影响青光眼，可能涉及年龄和性别等其他因素。在这项回顾性研究中,我们的目的是调查年龄之间的关联，性别,DM,HTN,和青光眼的风险。我们采用了使用200×200像素光学立方体进行的光学相干断层扫描（OCT）（CirrusHDOCT6000，版本10.0；CarlZeissMeditec，都柏林,CA,美国）。忽略了低测试信号所掩盖的影响。数据来自1337名患者。其中,218和402名患者患有DM和HTN，分别,133（10％）同时表现出来。基于性别的比较显示，女性的视网膜神经纤维层（RNFL）和神经节细胞内网状层（GCIPL）厚度稍大。没有DM和HTN的患者主要在50和60岁，而DM和HTN在60岁和70岁的患者中最为普遍。在大多数患者中，RNFL和GCIPL厚度均随年龄增长而降低。研究表明，老年人比年轻人更容易患青光眼，DM和HTN患者的发病率较高，RNFL和GCIPL厚度降低。此外，在年龄增长之前的早期发现可以提供有价值的预防见解。
