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Abstract：
Blood serum of patients with gastric (n = 68) and esophageal (n = 43) cancer was assessed for proteolytic fragments of IgG. Serum samples of 20 healthy donors were used as a control. We analyzed indicators of hemostasis (prothrombin time, fibrinogen, plasminogen activity, a2-antiplasmin activity, protein C activity) in blood plasma and the level of total IgG in the blood serum. The median IgG-LysK of healthy donors was lower than in esophageal cancer and in patients with gastric cancer. ROC-analysis showed high sensitivity (91%) and specificity (85%) in the group with esophageal cancer but 68% and 85%, respectively, in patients with gastric cancer. Analysis of false negatives IgG-LysK in cancer patients showed that most patients had an advanced stage of cancer accompanied by metastases. Total IgG in the plasma of patients with false-negative IgG-LysK values was 30% lower than in samples with positive values, while the level of a2-antiplasmin was increased and the prothrombin time was shorter. These changes in blood homeostasis may be the reason for an increase in the proportion of false-negative values of the IgG-LysK coefficient. Circulatory IgG-LysK levels increase in the early stages of such cancers as gastric and esophageal cancers. Thus, when used in a panel with other more specific markers for these pathologies, this indicator can significantly increase the early detection of cancer.
摘要：
评估胃癌（n=68）和食管癌（n=43）患者的血清中IgG的蛋白水解片段。20名健康供体的血清样品用作对照。我们分析了止血指标(凝血酶原时间，纤维蛋白原，纤溶酶原活性，a2-抗纤溶酶活性，蛋白C活性）在血浆中和血清中总IgG的水平。健康供者的IgG-LysK中位数低于食管癌和胃癌患者。ROC分析显示食管癌组的敏感性（91％）和特异性（85％）高，但68％和85％，分别,胃癌患者。对癌症患者的假阴性IgG-LysK的分析表明，大多数患者患有晚期癌症并伴有转移。IgG-LysK值假阴性患者血浆中的总IgG比阳性样品低30%，而α2-抗纤溶酶水平升高，凝血酶原时间缩短。血液稳态的这些变化可能是IgG-LysK系数的假阴性值比例增加的原因。循环IgG-LysK水平在胃癌和食道癌等癌症的早期阶段增加。因此，当与其他更具体的这些病理标记一起用于面板时，这一指标可以显著增加癌症的早期发现。
