PDF(Pubmed)
Abstract：
BACKGROUND: Preeclampsia (PE) and eclampsia (E) are severe pregnancy complications with significant maternal and neonatal health impacts. This study explores the association of the rs5707 polymorphism in the renin-angiotensin system (RAS) with PE/E and related neonatal outcomes.
METHODS: We conducted a cross-sectional study involving 400 mother-newborn dyads at the \"Pius Brinzeu\" Emergency Clinical Hospital Timisoara. Participants were divided into a control group (254 normotensive women) and a PE/E group (146 women with PE/E). Genotyping for the rs5707 polymorphism was performed using real-time PCR, and statistical analyses assessed associations with maternal body mass index (BMI) and neonatal outcomes.
RESULTS: The AA genotype of rs5707 was significantly associated with a reduced risk of PE/E and more favorable neonatal outcomes, including higher Apgar scores, greater birth weights, and longer gestational ages. Conversely, the AC genotype correlated with increased maternal BMI and adverse neonatal outcomes. Odds ratios highlighted the protective effect of the AA genotype against PE/E and the increased risk associated with the AC genotype.
CONCLUSIONS: This study revealed the critical role of the rs5707 polymorphism in PE/E development and neonatal health. Genetic screening for rs5707 could enhance early identification and personalized intervention strategies, improving outcomes for both mothers and neonates. Further research is needed to validate these findings across diverse populations and to uncover the underlying mechanisms.
METHODS: We conducted a cross-sectional study involving 400 mother-newborn dyads at the \"Pius Brinzeu\" Emergency Clinical Hospital Timisoara. Participants were divided into a control group (254 normotensive women) and a PE/E group (146 women with PE/E). Genotyping for the rs5707 polymorphism was performed using real-time PCR, and statistical analyses assessed associations with maternal body mass index (BMI) and neonatal outcomes.
RESULTS: The AA genotype of rs5707 was significantly associated with a reduced risk of PE/E and more favorable neonatal outcomes, including higher Apgar scores, greater birth weights, and longer gestational ages. Conversely, the AC genotype correlated with increased maternal BMI and adverse neonatal outcomes. Odds ratios highlighted the protective effect of the AA genotype against PE/E and the increased risk associated with the AC genotype.
CONCLUSIONS: This study revealed the critical role of the rs5707 polymorphism in PE/E development and neonatal health. Genetic screening for rs5707 could enhance early identification and personalized intervention strategies, improving outcomes for both mothers and neonates. Further research is needed to validate these findings across diverse populations and to uncover the underlying mechanisms.
摘要：
背景：先兆子痫（PE）和子痫（E）是严重的妊娠并发症，对孕产妇和新生儿健康有重大影响。这项研究探讨了肾素-血管紧张素系统（RAS）中rs5707多态性与PE/E和相关新生儿结局的关联。
方法：我们在“PiusBrinzeu”急诊临床医院Timisoara进行了一项涉及400个母婴双亲的横断面研究。参与者分为对照组（254名血压正常的女性）和PE/E组（146名患有PE/E的女性）。rs5707多态性的基因分型使用实时PCR进行，统计分析评估了孕妇体重指数(BMI)和新生儿结局的相关性.
结果：AA基因型rs5707与PE/E的风险降低和更有利的新生儿结局显着相关，包括更高的阿普加分数,更大的出生体重，和更长的胎龄。相反，AC基因型与孕妇BMI增加和不良新生儿结局相关.赔率比突出了AA基因型对PE/E的保护作用和与AC基因型相关的增加的风险。
结论：本研究揭示了rs5707多态性在PE/E发育和新生儿健康中的关键作用。rs5707的基因筛查可以增强早期识别和个性化干预策略，改善母亲和新生儿的结局。需要进一步的研究来验证不同人群的这些发现，并揭示潜在的机制。
方法：我们在“PiusBrinzeu”急诊临床医院Timisoara进行了一项涉及400个母婴双亲的横断面研究。参与者分为对照组（254名血压正常的女性）和PE/E组（146名患有PE/E的女性）。rs5707多态性的基因分型使用实时PCR进行，统计分析评估了孕妇体重指数(BMI)和新生儿结局的相关性.
结果：AA基因型rs5707与PE/E的风险降低和更有利的新生儿结局显着相关，包括更高的阿普加分数,更大的出生体重，和更长的胎龄。相反，AC基因型与孕妇BMI增加和不良新生儿结局相关.赔率比突出了AA基因型对PE/E的保护作用和与AC基因型相关的增加的风险。
结论：本研究揭示了rs5707多态性在PE/E发育和新生儿健康中的关键作用。rs5707的基因筛查可以增强早期识别和个性化干预策略，改善母亲和新生儿的结局。需要进一步的研究来验证不同人群的这些发现，并揭示潜在的机制。
