PDF(Pubmed)
Abstract：
In Sicily (Italy), respiratory syncytial virus (RSV), rhinovirus (HRV), and influenza virus triggered epidemics among children, resulting in an increase in acute respiratory tract infections (ARTIs). Our objective was to capture the epidemiology of respiratory infections in children, determining which pathogens were associated with respiratory infections following the lockdown and whether there were changes in the epidemiological landscape during the post-SARS-CoV-2 pandemic era.
METHODS: We analyzed multiplex respiratory viral PCR data (BioFire® FilmArray® Respiratory Panel 2.1 Plus) from 204 children presenting with respiratory symptoms and/or fever to our Unit of Pediatrics and Pediatric Emergency.
RESULTS: Viruses were predominantly responsible for ARTIs (99%), with RSV emerging as the most common agent involved in respiratory infections, followed by human rhinovirus/enterovirus and influenza A. RSV and rhinovirus were also the primary agents in coinfections. RSV predominated during winter months, while HRV/EV exhibited greater prevalence than RSV during the fall. Some viruses spread exclusively in coinfections (human coronavirus NL63, adenovirus, metapneumovirus, and parainfluenza viruses 1-3), while others primarily caused mono-infections (influenza A and B). SARS-CoV-2 was detected equally in both mono-infections (41%) and coinfections (59%).
CONCLUSIONS: Our analysis underlines the predominance of RSV and the importance of implementing preventive strategies for RSV.
METHODS: We analyzed multiplex respiratory viral PCR data (BioFire® FilmArray® Respiratory Panel 2.1 Plus) from 204 children presenting with respiratory symptoms and/or fever to our Unit of Pediatrics and Pediatric Emergency.
RESULTS: Viruses were predominantly responsible for ARTIs (99%), with RSV emerging as the most common agent involved in respiratory infections, followed by human rhinovirus/enterovirus and influenza A. RSV and rhinovirus were also the primary agents in coinfections. RSV predominated during winter months, while HRV/EV exhibited greater prevalence than RSV during the fall. Some viruses spread exclusively in coinfections (human coronavirus NL63, adenovirus, metapneumovirus, and parainfluenza viruses 1-3), while others primarily caused mono-infections (influenza A and B). SARS-CoV-2 was detected equally in both mono-infections (41%) and coinfections (59%).
CONCLUSIONS: Our analysis underlines the predominance of RSV and the importance of implementing preventive strategies for RSV.
摘要：
在西西里（意大利），呼吸道合胞病毒（RSV），鼻病毒（HRV），流感病毒在儿童中引发了流行病，导致急性呼吸道感染（ARTI）增加。我们的目标是捕获儿童呼吸道感染的流行病学，确定封锁后哪些病原体与呼吸道感染相关,以及在SARS-CoV-2大流行后时期流行病学格局是否发生变化.
方法：我们分析了204名出现呼吸道症状和/或发热的儿童的多重呼吸道病毒PCR数据（BioFire®FilmArray®RespiratoryPanel2.1Plus）到我们的儿科和儿科急诊部门。
结果：病毒主要负责ARTI（99%），随着RSV成为涉及呼吸道感染的最常见药物，其次是人鼻病毒/肠道病毒和甲型流感。RSV和鼻病毒也是合并感染的主要药物。RSV在冬季占主导地位，而HRV/EV在跌倒期间的患病率高于RSV。一些病毒仅在共感染中传播(人类冠状病毒NL63，腺病毒，偏肺病毒，和副流感病毒1-3），而其他人主要引起单一感染（甲型和乙型流感）。SARS-CoV-2在单一感染（41％）和合并感染（59％）中均被检测到。
结论：我们的分析强调了RSV的优势以及实施RSV预防策略的重要性。
方法：我们分析了204名出现呼吸道症状和/或发热的儿童的多重呼吸道病毒PCR数据（BioFire®FilmArray®RespiratoryPanel2.1Plus）到我们的儿科和儿科急诊部门。
结果：病毒主要负责ARTI（99%），随着RSV成为涉及呼吸道感染的最常见药物，其次是人鼻病毒/肠道病毒和甲型流感。RSV和鼻病毒也是合并感染的主要药物。RSV在冬季占主导地位，而HRV/EV在跌倒期间的患病率高于RSV。一些病毒仅在共感染中传播(人类冠状病毒NL63，腺病毒，偏肺病毒，和副流感病毒1-3），而其他人主要引起单一感染（甲型和乙型流感）。SARS-CoV-2在单一感染（41％）和合并感染（59％）中均被检测到。
结论：我们的分析强调了RSV的优势以及实施RSV预防策略的重要性。
