PDF(Pubmed)
Abstract：
Despite the introduction of serological neoplastic biomarkers and typical radiological characteristics in clinical practice, liver biopsy (LB) is often still necessary to establish a histological diagnosis, especially in ambiguous cases. Nowadays, LB via the percutaneous approach (PC-LB), under computed tomography (CT) scan or ultrasonography (US) guidance, is the route of choice. However, certain focal liver lesions can be challenging to access percutaneously. In such cases, endoscopic ultrasound (EUS)-guided fine needle biopsy (FNB) may represent an attractive, minimally invasive alternative. This retrospective observational study aimed to evaluate the efficacy, diagnostic performance, and safety of EUS-FNB conducted on 58 focal liver lesions located in both liver lobes. The adequacy of FNB samples for focal liver lesions located in the left and right lobes was 100% and 81.2%, respectively, and the difference was statistically significant (p = 0.001). Technical success was 100% for both liver lobes. The overall sensitivity and specificity were 95% and 100%, respectively. EUS-FNB is effective in making an accurate diagnosis with an excellent safety profile for focal liver lesions located in both liver lobes.
摘要：
尽管在临床实践中引入了血清学肿瘤生物标志物和典型的放射学特征，肝活检（LB）通常仍然需要建立组织学诊断，尤其是在模棱两可的情况下。如今,经皮入路LB(PC-LB),在计算机断层扫描（CT）扫描或超声检查（US）指导下，是选择的路线。然而,某些局灶性肝脏病变可能具有挑战性。在这种情况下,内镜超声（EUS）引导的细针活检（FNB）可能代表一个有吸引力的，微创替代。这项回顾性观察性研究旨在评估疗效，诊断性能,EUS-FNB对位于两个肝叶的58个局灶性肝脏病变进行了安全性。FNB样本对位于左叶和右叶的局灶性肝脏病变的充分性分别为100％和81.2％，分别,差异有统计学意义(p=0.001)。两个肝叶的技术成功率均为100％。总体敏感性和特异性分别为95%和100%,分别。EUS-FNB可有效地对位于两个肝叶的局灶性肝脏病变进行准确的诊断，具有出色的安全性。
