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Abstract：
This study investigated the releasing dynamics of serum ST2 and calprotectin in patients with acute IS. The study included acute IS patients (N = 20) with an NIH Stroke Scale score ≥8. Sampling was performed at seven time points: after admission (T0) and at the following 24 h consecutive intervals (T1-T6). Primary outcome at 90 days was evaluated using the modified Rankin scale: 0-2 for good and 3-6 for poor functional outcome. The secondary outcome was all-cause mortality after 90 days. Fifteen patients had a poor outcome, and eight died. Results showed a statistically significant difference in ST2 concentrations between good and poor outcomes at T0 (p = 0.04), T1 (p = 0.006), T2 (p = 0.01), T3 (p = 0.021), T4 (p = 0.007), T5 (p = 0.032), and for calprotectin T6 (p = 0.034). Prognostic accuracy was highest for ST2 at T1 for a cut-off > 18.9 µg/L (sensitivity 80% and specificity 100.0%) and for calprotectin at T5 for a cut-off > 4.5 mg/L (sensitivity 64.3% and specificity 100.0%). Serum ST2 and calprotectin-releasing dynamics showed a valuable prognostic accuracy for IS outcomes.
摘要：
本研究调查了急性IS患者血清ST2和钙卫蛋白的释放动力学。该研究包括NIH卒中量表评分≥8的急性IS患者（N=20）。在七个时间点进行采样：入院后（T0）和随后的24小时连续间隔（T1-T6）。使用改良的Rankin量表评估90天的主要结局：0-2表示良好，3-6表示不良功能结局。次要结果是90天后的全因死亡率。15名患者预后不佳，八个人死亡。结果显示，在T0时，良好和不良结果之间的ST2浓度存在统计学上的显着差异（p=0.04），T1（p=0.006），T2（p=0.01），T3（p=0.021），T4（p=0.007），T5(p=0.032),以及钙卫蛋白T6(p=0.034)。ST2在T1时的预后准确性最高，截止值>18.9µg/L（灵敏度为80％，特异性为100.0％），在T5时钙卫蛋白的截止值>4.5mg/L（灵敏度为64.3％，特异性为100.0％）。血清ST2和钙卫蛋白释放动力学显示了IS结果的有价值的预后准确性。
