PDF(Pubmed)
Abstract：
Takayasu arteritis is a chronic inflammatory vasculitis with granulomatous panarteritis particularly impacting large vessels including the aorta and its branches, especially the subclavian arteries, with clinical manifestation dependent on the involved artery. Sequelae of the active disease vary, including stenosis, occlusions, or aneurysmal dilatations of the large vessels. The prevalence of Takayasu arteritis is higher in the Asian population and in Japan, but quite low in the United States, varying from 0.9-8.4 per million people. Ocular manifestations are rare and lead to a delay in diagnosis and appropriate treatment. Ocular manifestations include Takayasu retinopathy, anterior ischemic optic neuropathy (AION), retinal artery occlusion (RAO) and retinal vein occlusion (RVO). We present two cases in which central retinal artery occlusion (CRAO) was associated with Takayasu arteritis. CRAO is an ophthalmic emergency with an incidence of 1.9 per 100,000 person years in the United States; only 5% of cases are arteritic, which can be observed with inflammatory vasculitides secondary to the formation of immune deposits.
摘要：
Takayasu动脉炎是一种慢性炎症性血管炎，伴有肉芽肿性动脉炎，特别是影响包括主动脉及其分支在内的大血管。尤其是锁骨下动脉,临床表现取决于受累动脉。活动性疾病的后遗症各不相同，包括狭窄,闭塞,或大血管的动脉瘤扩张。在亚洲人群和日本，大动脉炎的患病率较高，但在美国很低，每百万人口0.9-8.4不等。眼部表现很少见，并导致诊断和适当治疗的延迟。眼部表现包括Takayasu视网膜病变，前部缺血性视神经病变（AION），视网膜动脉阻塞（RAO）和视网膜静脉阻塞（RVO）。我们介绍了两例视网膜中央动脉阻塞（CRAO）与Takayasu大动脉炎有关的病例。CRAO是一种眼科急症，在美国每100,000人年的发病率为1.9；只有5％的病例是动脉炎，这可以观察到继发于免疫沉积物形成的炎性血管炎。
