PDF(Pubmed)
Abstract：
Background and aims: The enhanced liver fibrosis (ELF) score is a blood test that combines three markers linked to liver fibrosis. The utility of the ELF score has been demonstrated primarily in Western countries, but whether it is useful in areas with a high number of elderly people suffering from chronic liver disease has yet to be determined. Methods: This is a prospective study that included 373 consecutive patients who underwent a liver biopsy and had their ELF score measured on the same day. The diagnostic accuracy of the ELF score for liver fibrosis and the effect of age on the ELF score were investigated. Results: The median (interquartile) ELF scores in F0, F1, F2, F3, and F4 are 8.7 (8.2-9.2), 9.3 (8.8-10.0), 10.1 (9.4-10.7), 10.7 (9.9-11.2), and 12.0 (11.2-12.7), respectively. ELF scores increased with increasing liver fibrosis stage (p < 0.001). The diagnostic accuracy of the ELF score and FIB-4 for significant fibrosis (F2-4) and advanced fibrosis (F3-4) was comparable, but the ELF score had a higher diagnostic accuracy for cirrhosis (F4) than FIB-4. When patients were stratified by age of 60 years, the median ELF score did not differ by age in F2, F3, and F4. However, the median FIB-4 increased in patients with ≥60 years compared to those with <60 years in all fibrosis stages. Conclusions: ELF score has high diagnostic accuracy for liver fibrosis, regardless of age, and it could be used as a primary screening method.
摘要：
背景和目的：增强肝纤维化（ELF）评分是一种血液测试，结合了与肝纤维化相关的三个标志物。ELF评分的实用性主要在西方国家得到了证明，但是它在患有慢性肝病的老年人众多的地区是否有用还有待确定。方法：这是一项前瞻性研究，包括373例连续接受肝活检的患者，并在同一天测量他们的ELF评分。探讨ELF评分对肝纤维化的诊断准确性及年龄对ELF评分的影响。结果：F0，F1，F2，F3和F4的中位（四分位数）ELF评分为8.7（8.2-9.2），9.3(8.8-10.0),10.1(9.4-10.7),10.7(9.9-11.2),和12.0（11.2-12.7），分别。ELF评分随着肝纤维化分期的增加而增加（p<0.001）。ELF评分和FIB-4对显著纤维化(F2-4)和晚期纤维化(F3-4)的诊断准确性相当,但ELF评分对肝硬化(F4)的诊断准确率高于FIB-4.当患者按60岁的年龄分层时，在F2,F3和F4中,ELF评分中位数无年龄差异.然而,在所有纤维化阶段,≥60岁患者的FIB-4中位数均高于<60岁患者.结论:ELF评分对肝纤维化具有较高的诊断准确性,不管年龄,它可以用作主要的筛选方法。
