PDF(Pubmed)
Abstract：
Molecular imaging modalities show valuable non-invasive techniques capable of precisely and selectively addressing molecular markers associated with prostate cancer (PCa). This systematic review provides an overview of imaging markers utilized in positron emission tomography (PET) methods, specifically focusing on the pathways and mediators involved in PCa. This systematic review aims to evaluate and analyse existing literature on the diagnostic accuracy of molecular imaging techniques for detecting PCa. The PubMed, EBSCO, ScienceDirect, and Web of Science databases were searched, identifying 32 studies that reported molecular imaging modalities for detecting PCa. Numerous imaging modalities and radiotracers were used to detect PCa, including 68Ga-prostate-specific membrane antigen (PSMA) PET/computed tomography (CT), 68Ga-PSMA-11 PET/magnetic resonance imaging (MRI), 18F-PSMA-1007 PET/CT, 18F-DCFPyL PET/MRI, 18F-choline PET/MRI, and 18F-fluoroethylcholine PET/MRI. Across 11 studies, radiolabelled 68Ga-PSMA PET/CT imaging had a pooled sensitivity of 80 (95% confidence interval [CI]: 35-93), specificity of 90 (95% CI: 71-98), and accuracy of 86 (95% CI: 64-96). The PSMA-ligand 68Ga-PET/CT showed good diagnostic performance and appears promising for detecting and staging PCa.
摘要：
分子成像模式显示了有价值的非侵入性技术，能够精确和选择性地解决与前列腺癌（PCa）相关的分子标志物。这篇系统综述概述了正电子发射断层扫描（PET）方法中使用的成像标记，特别关注PCa涉及的途径和介体。本系统综述旨在评估和分析有关分子成像技术检测PCa的诊断准确性的现有文献。PubMed,EBSCO,ScienceDirect,搜索了WebofScience数据库，确定了32项报道检测PCa的分子成像模式的研究。许多成像模式和放射性示踪剂被用来检测PCa，包括68Ga-前列腺特异性膜抗原（PSMA）PET/计算机断层扫描（CT），68Ga-PSMA-11PET/磁共振成像（MRI），18F-PSMA-1007PET/CT,18F-DCFPyLPET/MRI,18F-胆碱PET/MRI,和18F-氟乙基胆碱PET/MRI。在11项研究中，放射性标记的68Ga-PSMAPET/CT成像的合并灵敏度为80（95％置信区间[CI]：35-93），特异性为90（95%CI：71-98），准确度为86（95%CI：64-96）。PSMA-配体68Ga-PET/CT显示出良好的诊断性能，对于检测和分期PCa似乎很有希望。
