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Abstract：
Six derivatives of poly-N-vinylcaprolactam (PNVCL) P1-P6 were synthesized via surfactant-free precipitation polymerization (SFPP) at 70 °C, with potassium persulfate (KPS) as the initiator. P5 and P6 were synthesized using the cross-linker N,N\'-Methylenebisacrylamide (MBA). The conductivity was measured to monitor the polymerization process. The hydrodynamic diameters (HDs) and polydispersity indexes (PDIs) of aqueous dispersions of P1-P6 were determined using dynamic light scattering (DLS) and zeta potential (ZP) using electrophoretic mobilities. At 18 °C for P1-P6, the HDs (nm) were 428.32 ± 81.30 and PDI 0.31 ± 0.19, 528.60 ± 84.70 (PDI 0.42 ± 0,04), 425.96 ± 115.42 (PDI 0.56 ± 0.08), 440.34 ± 106.40 (PDI 0.52 ± 0.09), 198.39 ± 225.35 (PDI 0.40 ± 0.19), and 1201.52 ± 1318.05 (PDI 0.71 ± 0.30), the and ZPs were (mV) 0.90 ± 3.23, -4.46 ± 1.22, -6.44 ± 1.82, 0.22 ± 0.48, 0.18 ± 0.79, and -0.02 ± 0.39 for P1-P6, respectively. The lower critical solution temperature ranged from 27 to 29 °C. The polymers were characterized using the ATR-FTIR method. The study concluded that the physicochemical properties of the product were significantly affected by the initial reaction parameters. Polymers P1-P4 and P6 have potential for use as drug carriers for skin applications.
摘要：
在70°C下通过无表面活性剂沉淀聚合（SFPP）合成了六种聚-N-乙烯基己内酰胺（PNVCL）P1-P6的衍生物，以过硫酸钾(KPS)为引发剂。使用交联剂N合成P5和P6，N'-亚甲基双丙烯酰胺(MBA)。测量电导率以监测聚合过程。使用动态光散射（DLS）和ζ电位（ZP）使用电泳迁移率确定P1-P6水分散体的流体动力学直径（HD）和多分散指数（PDIs）。P1-P6在18°C时，HDs（nm）为428.32±81.30，PDI为0.31±0.19、528.60±84.70（PDI0.42±0.04），425.96±115.42（PDI0.56±0.08），440.34±106.40(PDI0.52±0.09),198.39±225.35（PDI0.40±0.19），和1201.52±1318.05（PDI0.71±0.30），P1-P6的ZP和ZP分别为（mV）0.90±3.23，-4.46±1.22，-6.44±1.82，0.22±0.48，0.18±0.79和-0.02±0.39。下临界溶液温度范围为27至29°C。使用ATR-FTIR方法表征聚合物。研究得出结论，初始反应参数对产物的理化性质有显著影响。聚合物P1-P4和P6具有用作皮肤应用的药物载体的潜力。
