PDF(Pubmed)
Abstract：
Chitosan (CS) has a natural origin and is a biodegradable and biocompatible polymer with many skin-beneficial properties successfully used in the cosmetics and pharmaceutical industry. CS derivatives, especially those synthesized via a Schiff base reaction, are very important due to their unique antimicrobial activity. This study demonstrates research results on the use of hydrogel microspheres made of [chitosan-graft-poly(ε-caprolactone)]-blend-(ĸ-carrageenan)], [chitosan-2-pyridinecarboxaldehyde-graft-poly(ε-caprolactone)]-blend-(ĸ-carrageenan), and chitosan-sodium-4-formylbenzene-1,3-disulfonate-graft-poly(ε-caprolactone)]-blend-(ĸ-carrageenan) as innovative vitamin carriers for cosmetic formulation. A permeation study of retinol (vitamin A), L-ascorbic acid (vitamin C), and α-tocopherol (vitamin E) from the cream through a human skin model by the Franz Cell measurement system was presented. The quantitative analysis of the release of the vitamins added to the cream base, through the membrane, imitating human skin, showed a promising profile of its release/penetration, which is promising for the development of a cream with anti-aging properties. Additionally, the antibacterial activity of the polymers from which the microspheres are made allows for the elimination of preservatives and parabens as cosmetic formulation ingredients.
摘要：
壳聚糖（CS）具有天然来源，是一种生物可降解且生物相容的聚合物，具有许多对皮肤有益的特性，已成功用于化妆品和制药行业。CS衍生物，尤其是通过席夫碱反应合成的那些，是非常重要的，由于其独特的抗菌活性。这项研究证明了使用由[壳聚糖-接枝-聚（ε-己内酯）]-共混物-（β-角叉菜胶）]制成的水凝胶微球的研究结果，[壳聚糖-2-吡啶甲醛-接枝-聚（ε-己内酯）]-共混物-（β-角叉菜胶），和壳聚糖-4-甲酰苯-1,3-二磺酸盐-接枝-聚（ε-己内酯）]-共混物-（β-角叉菜胶）作为化妆品配方的创新维生素载体。视黄醇（维生素A）的渗透研究，L-抗坏血酸（维生素C），提出了通过FranzCell测量系统通过人体皮肤模型从乳膏中获得的α-生育酚（维生素E）。添加到奶油基质中的维生素的释放的定量分析，穿过膜，模仿人类皮肤，显示了其释放/渗透的前景，这对于开发具有抗衰老性能的乳霜是有希望的。此外,制备微球的聚合物的抗菌活性允许消除作为化妆品制剂成分的防腐剂和对羟基苯甲酸酯。
