PDF(Pubmed)
Abstract：
Hydrogels have been extensively studied for biomedical applications such as drug delivery, tissue-engineered scaffolds, and biosensors. There is a gap in the literature pertaining to the mechanical properties of hydrogel materials subjected to high-strain dynamic-loading conditions even though empirical data of this type are needed to advance the design of innovative biomedical designs and inform numerical models. For this work, HEMA-DMAEMA hydrogels are fabricated using a photopolymerization approach. Hydrogels are subjected to high-compression oscillatory dynamic mechanical loading at strain rates equal to 50%, 60%, and 70%, and storage and loss moduli are observed over time, e.g., 72 h and 5, 10, and 15 days. As expected, the increased strains resulted in lower storage and loss moduli, which could be attributed to a breakdown in the hydrogel network attributed to several mechanisms, e.g., increased network disruption, chain scission or slippage, and partial plastic deformation. This study helps to advance our understanding of hydrogels subjected to high strain rates to understand their viscoelastic behavior, i.e., strain rate sensitivity, energy dissipation mechanisms, and deformation kinetics, which are needed for the accurate modeling and prediction of hydrogel behavior in real-world applications.
摘要：
水凝胶已被广泛研究用于生物医学应用，如药物递送，组织工程支架，和生物传感器。尽管需要这种类型的经验数据来推进创新的生物医学设计的设计并为数值模型提供信息，但文献中关于经受高应变动态载荷条件的水凝胶材料的机械性能存在差距。对于这项工作，使用光聚合方法制造HEMA-DMAEMA水凝胶。水凝胶以等于50％的应变率承受高压缩振荡动态机械载荷，60%,70%,随着时间的推移，观察到储存和损耗模量，例如，72h和5、10和15天。不出所料,增加的菌株导致较低的储存和损耗模量，这可能归因于水凝胶网络的破坏，例如，网络中断增加，链条断裂或打滑，和部分塑性变形。这项研究有助于促进我们对承受高应变率的水凝胶的理解，以了解其粘弹性行为，即，应变率灵敏度,能量耗散机制，和变形动力学，在实际应用中，需要对水凝胶行为进行精确建模和预测。
