PDF(Pubmed)
Abstract：
While conventional medicine has advanced in recent years, there are still concerns about its potential adverse reactions. The ethnopharmacological knowledge established over many centuries and the existence of a variety of metabolites have made medicinal plants, such as the stinging nettle plant, an invaluable resource for treating a wide range of health conditions, considering its minimal adverse effects on human health. The aim of this review is to highlight the therapeutic benefits and biological activities of the edible Urtica dioica (UD) plant with an emphasis on its selective chemo-preventive properties against various types of cancer, whereby we decipher the mechanism of action of UD on various cancers including prostate, breast, leukemia, and colon in addition to evaluating its antidiabetic, microbial, and inflammatory properties. We further highlight the systemic protective effects of UD on the liver, reproductive, excretory, cardiovascular, nervous, and digestive systems. We present a critical assessment of the results obtained from in vitro and in vivo studies as well as clinical trials to highlight the gaps that require further exploration for future prospective studies.
摘要：
虽然近年来传统医学取得了进步，人们仍然担心其潜在的不良反应。许多世纪以来建立的民族药理学知识和各种代谢物的存在使药用植物，比如刺痛的荨麻植物，治疗各种健康状况的宝贵资源，考虑到它对人类健康的最小不利影响。这篇综述的目的是强调可食用的荨麻（UD）植物的治疗益处和生物活性，重点是其对各种类型癌症的选择性化学预防特性，由此我们破译了UD对包括前列腺癌在内的各种癌症的作用机制，乳房,白血病,和结肠除了评估其抗糖尿病药，微生物，和炎症特性。我们进一步强调UD对肝脏的全身保护作用，生殖,排泄,心血管,紧张,和消化系统。我们对从体外和体内研究以及临床试验中获得的结果进行了严格的评估，以突出需要进一步探索未来前瞻性研究的差距。
