PDF(Pubmed)
Abstract：
Non-coding RNAs (ncRNAs) are a heterogeneous group, in terms of structure and sequence length, consisting of RNA molecules that do not code for proteins. These ncRNAs have a central role in the regulation of gene expression and are virtually involved in every process analyzed, ensuring cellular homeostasis. Although, over the years, much research has focused on the characterization of non-coding transcripts of nuclear origin, improved bioinformatic tools and next-generation sequencing (NGS) platforms have allowed the identification of hundreds of ncRNAs transcribed from the mitochondrial genome (mt-ncRNA), including long non-coding RNA (lncRNA), circular RNA (circRNA), and microRNA (miR). Mt-ncRNAs have been described in diverse cellular processes such as mitochondrial proteome homeostasis and retrograde signaling; however, the function of the majority of mt-ncRNAs remains unknown. This review focuses on a subgroup of human mt-ncRNAs whose dysfunction is associated with both failures in cell cycle regulation, leading to defects in cell growth, cell proliferation, and apoptosis, and the development of tumor hallmarks, such as cell migration and metastasis formation, thus contributing to carcinogenesis and tumor development. Here we provide an overview of the mt-ncRNAs/cancer relationship that could help the future development of new biomedical applications in the field of oncology.
摘要：
非编码RNA（ncRNAs）是一个异质组，在结构和序列长度方面，由不编码蛋白质的RNA分子组成。这些ncRNAs在基因表达的调控中起着核心作用，并且几乎参与了所分析的每个过程，确保细胞内稳态。虽然,多年来,许多研究集中在核起源的非编码转录物的表征上，改进的生物信息学工具和下一代测序（NGS）平台已经允许鉴定数百种从线粒体基因组转录的ncRNA（mt-ncRNA），包括长链非编码RNA（lncRNA），环状RNA，和microRNA(miR)。Mt-ncRNAs已经在不同的细胞过程中被描述，如线粒体蛋白质组稳态和逆行信号传导；然而，大多数mt-ncRNAs的功能仍然未知。这篇综述集中于人类mt-ncRNAs的一个亚组，其功能障碍与细胞周期调节的失败有关。导致细胞生长缺陷，细胞增殖，和细胞凋亡，和肿瘤标志的发展，如细胞迁移和转移形成，从而促进癌的发生和肿瘤的发展。在这里，我们提供了mt-ncRNAs/癌症关系的概述，这可能有助于肿瘤学领域新的生物医学应用的未来发展。
