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Abstract：
In recent years, the worldwide epidemic of metabolic diseases, namely obesity, metabolic syndrome, diabetes and metabolic-associated fatty liver disease (MAFLD) has been strongly associated with constant exposure to endocrine-disruptive chemicals (EDCs), in particular, the ones able to disrupt various metabolic pathways. EDCs have a negative impact on several human tissues/systems, including metabolically active organs, such as the liver and pancreas. Among their deleterious effects, EDCs induce mitochondrial dysfunction and oxidative stress, which are also the major pathophysiological mechanisms underlying metabolic diseases. In this narrative review, we delve into the current literature on EDC toxicity effects on the liver and pancreatic tissues in terms of impaired mitochondrial function and redox homeostasis.
摘要：
近年来,代谢性疾病的全球流行，即肥胖，代谢综合征,糖尿病和代谢相关脂肪性肝病（MAFLD）与持续暴露于内分泌破坏性化学物质（EDC）密切相关。特别是,那些能够破坏各种代谢途径的。EDC对几种人体组织/系统有负面影响，包括代谢活跃的器官，比如肝脏和胰腺。在它们的有害影响中，EDC诱导线粒体功能障碍和氧化应激,这也是代谢疾病的主要病理生理机制。在这篇叙述性评论中，我们从线粒体功能受损和氧化还原稳态方面深入研究了EDC对肝脏和胰腺组织的毒性作用。
